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The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

BACKGROUND: The dynamics of histone post-translational modifications (PTMs) are sparsely described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs). METHODS: Here we time-resolve the response of cells to SUV4-20 methyltransferas...

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Detalles Bibliográficos
Autores principales:	Wang, Tao, Holt, Matthew V., Young, Nicolas L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992683/ https://www.ncbi.nlm.nih.gov/pubmed/29880017 http://dx.doi.org/10.1186/s13072-018-0198-9

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