Cargando…

Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature

BACKGROUND: The genetic profile for human papilloma virus positive (HPV+) oropharyngeal squamous cell carcinomas (OPSCC) remains largely unknown. The purpose of this study was to sequence tissue material from a large cohort of locoregionally-advanced HPV+ OPSCCs. METHODS: We performed targeted deep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grønhøj, Christian, Jensen, David H., Agander, Tina, Kiss, Katalin, Høgdall, Estrid, Specht, Lena, Bagger, Frederik Otzen, Nielsen, Finn Cilius, von Buchwald, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992702/ https://www.ncbi.nlm.nih.gov/pubmed/29879932 http://dx.doi.org/10.1186/s12885-018-4567-3

Ejemplares similares

Novel nomograms for survival and progression in HPV+ and HPV- oropharyngeal cancer: a population-based study of 1,542 consecutive patients
por: Larsen, Christian Grønhøj, et al.
Publicado: (2016)

Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010
por: Avnstorp, Magnus Balslev, et al.
Publicado: (2013)

Unveiling mRNP composition by fluorescence correlation and cross-correlation spectroscopy using cell lysates
por: Mateu-Regué, Àngels, et al.
Publicado: (2021)

Deconvolution of autoencoders to learn biological regulatory modules from single cell mRNA sequencing data
por: Kinalis, Savvas, et al.
Publicado: (2019)

The Incidence, Survival, and HPV Impact of Second Primary Cancer following Primary Oropharyngeal Squamous Cell Carcinoma: A 20-Year Retrospective and Population-Based Study
por: Andersen, Lasse, et al.
Publicado: (2022)

Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
por: Jensen, David Hebbelstrup, et al.
Publicado: (2014)

Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review
por: Grønhøj Larsen, C, et al.
Publicado: (2014)

Interpretable Autoencoders Trained on Single Cell Sequencing Data Can Transfer Directly to Data from Unseen Tissues
por: Walbech, Julie Sparholt, et al.
Publicado: (2021)

The Effect of Prophylactic HPV Vaccines on Oral and Oropharyngeal HPV Infection—A Systematic Review
por: Nielsen, Kristoffer Juul, et al.
Publicado: (2021)

Benchmarking full-length transcript single cell mRNA sequencing protocols
por: Probst, Victoria, et al.
Publicado: (2022)

Expression patterns of uPAR, TF and EGFR and their potential as targets for molecular imaging in oropharyngeal squamous cell carcinoma
por: Christensen, Anders, et al.
Publicado: (2022)

Transoral Ultrasound in the Outpatient Clinic for the Diagnostic Work-Up of Oropharyngeal Cancer: A Feasibility Study
por: Garset-Zamani, Martin, et al.
Publicado: (2023)

Cause‐specific mortality in HPV+ and HPV− oropharyngeal cancer patients: insights from a population‐based cohort
por: Nørregaard, Cecilie, et al.
Publicado: (2017)

First-in-man mesenchymal stem cells for radiation-induced xerostomia (MESRIX): study protocol for a randomized controlled trial
por: Grønhøj, Christian, et al.
Publicado: (2017)

Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
por: Grønhøj, Christian, et al.
Publicado: (2019)

Genomic Alterations in Human Papillomavirus–Positive and –Negative Conjunctival Squamous Cell Carcinomas
por: Ramberg, Ingvild, et al.
Publicado: (2021)

A Contemporary Systematic Review on Repartition of HPV-Positivity in Oropharyngeal Cancer Worldwide
por: Carlander, Amanda F., et al.
Publicado: (2021)

Oropharyngeal Cancer Epidemic and Human Papillomavirus
por: Ramqvist, Torbjörn, et al.
Publicado: (2010)

Construction of a pathological risk model of occult lymph node metastases for prognostication by semi-automated image analysis of tumor budding in early-stage oral squamous cell carcinoma
por: Pedersen, Nicklas Juel, et al.
Publicado: (2017)

Diagnostic Accuracy of HPV Detection in Patients with Oropharyngeal Squamous Cell Carcinomas: A Systematic Review and Meta-Analysis
por: Jakobsen, Kathrine Kronberg, et al.
Publicado: (2021)

Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)
por: Grønhøj, Christian, et al.
Publicado: (2018)

Amplicon-Based NGS Panels for Actionable Cancer Target Identification in Follicular Cell-Derived Thyroid Neoplasia
por: Madsen, Majbritt Busk, et al.
Publicado: (2020)

Evidence of No Association Between Human Papillomavirus and Breast Cancer
por: Bønløkke, Sara, et al.
Publicado: (2018)

Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer
por: Seol, Seung Won, et al.
Publicado: (2022)

Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies
por: Jakobsen, Kathrine Kronberg, et al.
Publicado: (2017)

Pretreatment Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for the Outcome of HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma
por: Justesen, Marius Meldgaard, et al.
Publicado: (2023)

Long-term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients with Radiation-Induced Xerostomia: Primary Results of the MESRIX Phase I/II Randomized Trial
por: Lynggaard, Charlotte Duch, et al.
Publicado: (2022)

BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles
por: Bagger, Frederik Otzen, et al.
Publicado: (2019)

Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling
por: Bagger, Frederik Otzen, et al.
Publicado: (2016)

El loco
por: Goetz, Rainald

Locos egregios
por: Vallejo-Nágera, Juan Antonio, 1926-
Publicado: (1980)

Oro loco
por: Giovaninetti, Silvio
Publicado: (1954)

El loco
por: Gibran, Kahlil, 1883-1931
Publicado: (1979)

Locoed Horses
por: McCullaugh, Frank A.
Publicado: (1892)

Modelling human papillomavirus biology in oropharyngeal keratinocytes
por: Roberts, Sally, et al.
Publicado: (2019)

Locos : una comedia de gestos /
por: Alfau, Felipe, 1902-
Publicado: (1990)

Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy
por: DALIANIS, TINA
Publicado: (2014)

Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring: A Systematic Review of Preclinical Studies
por: Wingstrand, Vibe Lindeblad, et al.
Publicado: (2016)

The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes
por: Harrowfield, Jane, et al.
Publicado: (2021)

El loco ; El vagabundo /
por: Gibran, Kahlil, 1883-1931
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ttmnap1373lckh4t9luhg15sdg