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The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD)

BACKGROUND: Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fraction of cancer patients and the success makes PD-1 as a valuable target in immun...

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Detalles Bibliográficos
Autores principales:	Du, Jiangfeng, Qin, Yaping, Wu, Yahong, Zhao, Wenshan, Zhai, Wenjie, Qi, Yuanming, Wang, Chuchu, Gao, Yanfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992718/ https://www.ncbi.nlm.nih.gov/pubmed/29879980 http://dx.doi.org/10.1186/s12964-018-0239-9

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