Cargando…

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

BACKGROUND: IL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony ankylosis. Here, we investigated the effects of anti IL-17A agents in AS. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jo, Sungsin, Wang, Sung Eun, Lee, Young Lim, Kang, Suman, Lee, Bitnara, Han, Jinil, Sung, Il-Hoon, Park, Ye-Soo, Bae, Sang-Cheol, Kim, Tae-Hwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992730/ https://www.ncbi.nlm.nih.gov/pubmed/29880011 http://dx.doi.org/10.1186/s13075-018-1582-3

Ejemplares similares

Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis
por: Jo, Sungsin, et al.
Publicado: (2023)

WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis
por: Jo, Sungsin, et al.
Publicado: (2021)

Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis
por: Jo, Sungsin, et al.
Publicado: (2020)

Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A‐RUNX2 pathway
por: Weon, Subin, et al.
Publicado: (2023)

The TNF-NF-kB-DKK1 Axis Promoted Bone Formation in the Enthesis of Ankylosing Spondylitis
por: Jo, Sungsin, et al.
Publicado: (2021)

Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis
por: Koo, Bon San, et al.
Publicado: (2020)

Clinical and genetic factors associated with radiographic damage in patients with ankylosing spondylitis
por: Nam, Bora, et al.
Publicado: (2023)

New insights into IL-17/IL-23 signaling in ankylosing spondylitis (Review)
por: Chisălău, Beatrice Andreea, et al.
Publicado: (2020)

Cervical spine fracture in advanced ankylosing spondylitis
por: Lee, Jennifer, et al.
Publicado: (2014)

Clonorchis sinensis-Derived Protein Attenuates Inflammation and New Bone Formation in Ankylosing Spondylitis
por: Lee, Yu Jeong, et al.
Publicado: (2021)

Biological and genetic evaluation of IL-23/IL-17 pathway in ankylosing spondylitis patients
por: DEVECI, HULYA, et al.
Publicado: (2020)

Ankylosing spondylitis: analysis of gene-gene interactions between IL-12β, JAK2, and STAT3 in Han Chinese and Algerian cohorts
por: Saadi, Ahlem, et al.
Publicado: (2019)

High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation
por: Lee, Eun-Ju, et al.
Publicado: (2015)

DKK1 Induced by 1,25D3 Is Required for the Mineralization of Osteoblasts
por: Jo, Sungsin, et al.
Publicado: (2020)

Interleukin-17 Inhibitors for the Treatment of Ankylosing Spondylitis
por: Huang, Jin-Xian, et al.
Publicado: (2020)

Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress
por: Feng, Xinzhe, et al.
Publicado: (2020)

The Epidemiology and Treatment of Ankylosing Spondylitis in Korea
por: Kwon, Seong-Ryul, et al.
Publicado: (2022)

Higher prevalence of peripheral arthritis among ankylosing spondylitis patients.
por: Lee, Ji-Hyun, et al.
Publicado: (2002)

Ezetimibe ameliorates clinical symptoms in a mouse model of ankylosing spondylitis associated with suppression of Th17 differentiation
por: Moon, Jeonghyeon, et al.
Publicado: (2022)

IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients
por: Milanez, Fernanda Manente, et al.
Publicado: (2016)

CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts
por: Jo, Sungsin, et al.
Publicado: (2019)

Neutrophil Extracellular Traps and Interleukin 17 in Ankylosing Spondylitis
por: Papagoras, Charalampos, et al.
Publicado: (2021)

Frequency of peripheral diseases in Korean patients with ankylosing spondylitis and the effectiveness of adalimumab
por: Lee, Sang‐Hoon, et al.
Publicado: (2020)

Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis
por: Braga, Matheus, et al.
Publicado: (2021)

Ankylosing spondylitis
Publicado: (1980)

Ankylosing spondylitis
por: Edavalath, Mukesh
Publicado: (2010)

Ankylosing Spondylitis
por: Whitfield, A. G. W.
Publicado: (1976)

Ankylosing Spondylitis
por: Ebrahimiadib, Nazanin, et al.
Publicado: (2021)

Bath Ankylosing Spondylitis Disease Activity Index is Associated With the Quality of Sleep in Ankylosing Spondylitis Patients
por: Song, Byung Wook, et al.
Publicado: (2021)

Palmoplantar pustulosis secondary to anti-tumor necrosis factor therapy in a patient with ankylosing spondylitis
por: Bae, Jung Min, et al.
Publicado: (2020)

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population
por: Yang, Bin, et al.
Publicado: (2017)

IL23R gene variants in relation to IL17A levels and clinical phenotype in patients with ankylosing spondylitis
por: Nossent, Johannes C, et al.
Publicado: (2018)

Immune activation of characteristic gut mycobiota Kazachstania pintolopesii on IL-23/IL-17R signaling in ankylosing spondylitis
por: Zhang, Haiting, et al.
Publicado: (2022)

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis
por: Vidal-Castiñeira, Jose Ramón, et al.
Publicado: (2016)

Efficacy and safety of IL-17 inhibitors for the treatment of ankylosing spondylitis: a systematic review and meta-analysis
por: Yin, Yufeng, et al.
Publicado: (2020)

Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis
por: Wielińska, Joanna, et al.
Publicado: (2021)

Surgical Treatment of Lumbar Hyperextension Injury in Ankylosing Spondylitis
por: Lee, Jung Keun, et al.
Publicado: (2013)

Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
por: Rabelo, Cristina F, et al.
Publicado: (2018)

Complete Fusion of Three Lumbar Vertebral Bodies in Ankylosing Spondylitis
por: Kim, Dong Hyun, et al.
Publicado: (2020)

Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis
por: McGonagle, Dennis, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e4u9qohvliur034fcmnb1ahmvv