CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

The APPswe (Swedish) mutation in the amyloid precursor protein (APP) gene causes dominantly inherited Alzheimer’s disease (AD) as a result of increased β-secretase cleavage of the amyloid-β (Aβ) precursor protein. This leads to abnormally high Aβ levels, not only in brain but also in peripheral tiss...

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Detalles Bibliográficos
Autores principales: György, Bence, Lööv, Camilla, Zaborowski, Mikołaj P., Takeda, Shuko, Kleinstiver, Benjamin P., Commins, Caitlin, Kastanenka, Ksenia, Mu, Dakai, Volak, Adrienn, Giedraitis, Vilmantas, Lannfelt, Lars, Maguire, Casey A., Joung, J. Keith, Hyman, Bradley T., Breakefield, Xandra O., Ingelsson, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992788/
https://www.ncbi.nlm.nih.gov/pubmed/29858078
http://dx.doi.org/10.1016/j.omtn.2018.03.007

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