Data on specificity of [(18)F]GE180 uptake for TSPO expression in rodent brain and myocardium

Data in this article show radioligand uptake (to gamma counter and positron-emission-tomography) as well as polymerase chain reaction analyses of 18 kDa translocator protein (TSPO) quantification. We confirmed specificity of [(18)F]GE180 binding of rodent brain and myocardium by blocking experiments...

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Detalles Bibliográficos
Autores principales: Deussing, Maximilian, Blume, Tanja, Vomacka, Lena, Mahler, Christoph, Focke, Carola, Todica, Andrei, Unterrainer, Marcus, Albert, Nathalie L., Lindner, Simon, von Ungern-Sternberg, Barbara, Baumann, Karlheinz, Zwergal, Andreas, Bartenstein, Peter, Herms, Jochen, Rominger, Axel, Brendel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992977/
https://www.ncbi.nlm.nih.gov/pubmed/29892655
http://dx.doi.org/10.1016/j.dib.2018.04.133
Descripción
Sumario:Data in this article show radioligand uptake (to gamma counter and positron-emission-tomography) as well as polymerase chain reaction analyses of 18 kDa translocator protein (TSPO) quantification. We confirmed specificity of [(18)F]GE180 binding of rodent brain and myocardium by blocking experiments with prior application of non-radioactive GE180, using dynamic in vivo positron-emission-tomography and ex vivo gamma counter measurements. Expression of TSPO was compared between rodent brain and myocardium by quantitative polymerase chain reaction.

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