Depletion of S100A4(+) stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors

There is a pressing need for the development of novel approaches to treat and prevent hepatocellular carcinoma (HCC). The S100 calcium-binding protein S100A4 is associated with poor prognosis and metastasis in several human cancers. In addition, a role for S100A4 in modulating cancer-initiating cell...

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Detalles Bibliográficos
Autores principales: Jiao, Jingjing, González, Álvaro, Stevenson, Heather L, Gagea, Mihai, Sugimoto, Hikaru, Kalluri, Raghu, Beretta, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992984/
https://www.ncbi.nlm.nih.gov/pubmed/29303514
http://dx.doi.org/10.1038/emm.2017.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992984/
https://www.ncbi.nlm.nih.gov/pubmed/29303514
http://dx.doi.org/10.1038/emm.2017.175

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