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Depletion of S100A4(+) stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors
There is a pressing need for the development of novel approaches to treat and prevent hepatocellular carcinoma (HCC). The S100 calcium-binding protein S100A4 is associated with poor prognosis and metastasis in several human cancers. In addition, a role for S100A4 in modulating cancer-initiating cell...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992984/ https://www.ncbi.nlm.nih.gov/pubmed/29303514 http://dx.doi.org/10.1038/emm.2017.175 |