Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator

Loss of integrity of the blood-brain barrier (BBB) in ischemic stroke victims initiates a devastating cascade of events causing brain damage. Maintaining the BBB is important to preserve brain function in ischemic stroke. Unfortunately, recombinant tissue plasminogen activator (tPA), the only effect...

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Detalles Bibliográficos
Autores principales: Shimada, Yoshiaki, Shimura, Hideki, Tanaka, Ryota, Yamashiro, Kazuo, Koike, Masato, Uchiyama, Yasuo, Urabe, Takao, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993064/
https://www.ncbi.nlm.nih.gov/pubmed/29795667
http://dx.doi.org/10.1371/journal.pone.0198039

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