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Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo

BACKGROUND: Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia-inducible factor-1α (HIF-1α) is overexpressed in nasopharyngeal carcinoma (NPC) tissues,...

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Detalles Bibliográficos
Autores principales:	Huang, Yan, Tian, Ying, Zhao, Yuanyuan, Xue, Cong, Zhan, Jianhua, Liu, Lin, He, Xiaobo, Zhang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993153/ https://www.ncbi.nlm.nih.gov/pubmed/29764490 http://dx.doi.org/10.1186/s40880-018-0285-0

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