De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions

De novo biosynthesis of lipids is essential for Trypanosoma brucei, a protist responsible for the sleeping sickness. Here, we demonstrate that the ketogenic carbon sources, threonine, acetate and glucose, are precursors for both fatty acid and sterol synthesis, while leucine only contributes to ster...

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Detalles Bibliográficos
Autores principales: Millerioux, Yoann, Mazet, Muriel, Bouyssou, Guillaume, Allmann, Stefan, Kiema, Tiila-Riikka, Bertiaux, Eloïse, Fouillen, Laetitia, Thapa, Chandan, Biran, Marc, Plazolles, Nicolas, Dittrich-Domergue, Franziska, Crouzols, Aline, Wierenga, Rik K., Rotureau, Brice, Moreau, Patrick, Bringaud, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993337/
https://www.ncbi.nlm.nih.gov/pubmed/29813135
http://dx.doi.org/10.1371/journal.ppat.1007116

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