A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia

The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts,...

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Detalles Bibliográficos
Autores principales: Hofmans, Mattias, Delie, Anke, Vandepoele, Karl, Van Roy, Nadine, Van der Meulen, Joni, Philippé, Jan, Moors, Ine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993353/
https://www.ncbi.nlm.nih.gov/pubmed/29892549
http://dx.doi.org/10.1016/j.lrr.2018.04.001
Descripción
Sumario:The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts, with high risk of transformation to acute leukemia. We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS.

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