A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia

The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts,...

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Autores principales: Hofmans, Mattias, Delie, Anke, Vandepoele, Karl, Van Roy, Nadine, Van der Meulen, Joni, Philippé, Jan, Moors, Ine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993353/
https://www.ncbi.nlm.nih.gov/pubmed/29892549
http://dx.doi.org/10.1016/j.lrr.2018.04.001
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author Hofmans, Mattias
Delie, Anke
Vandepoele, Karl
Van Roy, Nadine
Van der Meulen, Joni
Philippé, Jan
Moors, Ine
author_facet Hofmans, Mattias
Delie, Anke
Vandepoele, Karl
Van Roy, Nadine
Van der Meulen, Joni
Philippé, Jan
Moors, Ine
author_sort Hofmans, Mattias
collection PubMed
description The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts, with high risk of transformation to acute leukemia. We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS.
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spelling pubmed-59933532018-06-11 A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia Hofmans, Mattias Delie, Anke Vandepoele, Karl Van Roy, Nadine Van der Meulen, Joni Philippé, Jan Moors, Ine Leuk Res Rep Article The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts, with high risk of transformation to acute leukemia. We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS. Elsevier 2018-04-09 /pmc/articles/PMC5993353/ /pubmed/29892549 http://dx.doi.org/10.1016/j.lrr.2018.04.001 Text en © 2018 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hofmans, Mattias
Delie, Anke
Vandepoele, Karl
Van Roy, Nadine
Van der Meulen, Joni
Philippé, Jan
Moors, Ine
A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
title A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
title_full A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
title_fullStr A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
title_full_unstemmed A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
title_short A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
title_sort case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993353/
https://www.ncbi.nlm.nih.gov/pubmed/29892549
http://dx.doi.org/10.1016/j.lrr.2018.04.001
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