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Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes

Doxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxic...

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Detalles Bibliográficos
Autores principales:	Ramachandran, Sandhiya, Loganathan, Swetha, Cheeran, Vinnie, Charles, Soniya, Munuswamy-Ramanujan, Ganesh, Ramasamy, Mohankumar, Raj, Vijay, Mala, Kanchana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993357/ https://www.ncbi.nlm.nih.gov/pubmed/29892545 http://dx.doi.org/10.1016/j.lrr.2018.02.001

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