Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury

Posttraumatic Stress Disorder (PTSD) is a devastating condition that can develop after blast Traumatic Brain Injury (TBI). Ongoing work has been performed to understand how PTSD develops after injury. In this review, we highlight how PTSD affects individuals, discuss what is known about the physiolo...

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Autores principales: Lucke-Wold, Brandon, Nolan, Richard, Nwafor, Divine, Nguyen, Linda, Cheyuo, Cletus, Turner, Ryan, Rosen, Charles, Marsh, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993449/
https://www.ncbi.nlm.nih.gov/pubmed/29888766
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author Lucke-Wold, Brandon
Nolan, Richard
Nwafor, Divine
Nguyen, Linda
Cheyuo, Cletus
Turner, Ryan
Rosen, Charles
Marsh, Robert
author_facet Lucke-Wold, Brandon
Nolan, Richard
Nwafor, Divine
Nguyen, Linda
Cheyuo, Cletus
Turner, Ryan
Rosen, Charles
Marsh, Robert
author_sort Lucke-Wold, Brandon
collection PubMed
description Posttraumatic Stress Disorder (PTSD) is a devastating condition that can develop after blast Traumatic Brain Injury (TBI). Ongoing work has been performed to understand how PTSD develops after injury. In this review, we highlight how PTSD affects individuals, discuss what is known about the physiologic changes to the hypothalamic pituitary axis and neurotransmitter pathways, and present an overview of genetic components that may predispose individuals to developing PTSD. We then provide an overview of current treatment strategies to treat PTSD in veterans and present new strategies that may be useful going forward. The need for further clinical and pre-clinical studies is imperative to improve diagnosis, treatment, and management for patients that develop PTSD following blast TBI.
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spelling pubmed-59934492018-06-08 Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury Lucke-Wold, Brandon Nolan, Richard Nwafor, Divine Nguyen, Linda Cheyuo, Cletus Turner, Ryan Rosen, Charles Marsh, Robert J Neurosci Neuropharmacol Article Posttraumatic Stress Disorder (PTSD) is a devastating condition that can develop after blast Traumatic Brain Injury (TBI). Ongoing work has been performed to understand how PTSD develops after injury. In this review, we highlight how PTSD affects individuals, discuss what is known about the physiologic changes to the hypothalamic pituitary axis and neurotransmitter pathways, and present an overview of genetic components that may predispose individuals to developing PTSD. We then provide an overview of current treatment strategies to treat PTSD in veterans and present new strategies that may be useful going forward. The need for further clinical and pre-clinical studies is imperative to improve diagnosis, treatment, and management for patients that develop PTSD following blast TBI. 2018-03-02 2018 /pmc/articles/PMC5993449/ /pubmed/29888766 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Lucke-Wold, Brandon
Nolan, Richard
Nwafor, Divine
Nguyen, Linda
Cheyuo, Cletus
Turner, Ryan
Rosen, Charles
Marsh, Robert
Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury
title Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury
title_full Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury
title_fullStr Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury
title_full_unstemmed Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury
title_short Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury
title_sort post-traumatic stress disorder delineating the progression and underlying mechanisms following blast traumatic brain injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993449/
https://www.ncbi.nlm.nih.gov/pubmed/29888766
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