Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra-tumoral T-cells in mismatch repair-proficient li...

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Detalles Bibliográficos
Autores principales: Zhou, Guoying, Noordam, Lisanne, Sprengers, Dave, Doukas, Michail, Boor, Patrick P. C., van Beek, Adriaan A., Erkens, Remco, Mancham, Shanta, Grünhagen, Dirk, Menon, Anand G., Lange, Johan F., Burger, Pim J. W. A., Brandt, Alexandra, Galjart, Boris, Verhoef, Cornelis, Kwekkeboom, Jaap, Bruno, Marco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993483/
https://www.ncbi.nlm.nih.gov/pubmed/29900067
http://dx.doi.org/10.1080/2162402X.2018.1448332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993483/
https://www.ncbi.nlm.nih.gov/pubmed/29900067
http://dx.doi.org/10.1080/2162402X.2018.1448332

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