Cargando…

pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma

Interfering with tumor metabolism is an emerging strategy for treating cancers that are resistant to standard therapies. Featuring a rapid proliferation rate and exacerbated glycolysis, hepatocellular carcinoma (HCC) creates a highly hypoxic microenvironment with excessive production of lactic and c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuchuk, Olga, Tuccitto, Alessandra, Citterio, Davide, Huber, Veronica, Camisaschi, Chiara, Milione, Massimo, Vergani, Barbara, Villa, Antonello, Alison, Malcolm Ronald, Carradori, Simone, Supuran, Claudiu T, Rivoltini, Licia, Castelli, Chiara, Mazzaferro, Vincenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993489/ https://www.ncbi.nlm.nih.gov/pubmed/29900055 http://dx.doi.org/10.1080/2162402X.2018.1445452

Ejemplares similares

Targeting Immune Regulatory Networks to Counteract Immune Suppression in Cancer
por: Camisaschi, Chiara, et al.
Publicado: (2016)

Y(90)-radioembolisation in hepatocellular carcinoma induces immune responses calling for early treatment with multiple checkpoint blockers
por: Rivoltini, Licia, et al.
Publicado: (2023)

Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types
por: Tazzari, Marcella, et al.
Publicado: (2018)

microRNA Expression in Sentinel Nodes from Progressing Melanoma Patients Identifies Networks Associated with Dysfunctional Immune Response
por: Vallacchi, Viviana, et al.
Publicado: (2016)

Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients
por: Camisaschi, Chiara, et al.
Publicado: (2018)

MIAQuant, a novel system for automatic segmentation, measurement, and localization comparison of different biomarkers from serialized histological slices
por: Casiraghi, Elena, et al.
Publicado: (2017)

A novel computational method for automatic segmentation, quantification and comparative analysis of immunohistochemically labeled tissue sections
por: Casiraghi, Elena, et al.
Publicado: (2018)

Effects of cyclophosphamide and IL-2 on regulatory CD4(+) T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response
por: Camisaschi, Chiara, et al.
Publicado: (2013)

Structured myeloid cells and anti-angiogenic therapy in alveolar soft part sarcoma
por: Castelli, Chiara, et al.
Publicado: (2013)

Immune response markers in sentinel nodes may predict melanoma progression
por: Rodolfo, Monica, et al.
Publicado: (2014)

microRNAs Shape Myeloid Cell-Mediated Resistance to Cancer Immunotherapy
por: Daveri, Elena, et al.
Publicado: (2020)

Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report
por: Tazzari, Marcella, et al.
Publicado: (2015)

3D tumor explant as a novel platform to investigate therapeutic pathways and predictive biomarkers in cancer patients
por: Rodolfo, Monica, et al.
Publicado: (2022)

Circulating mir‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk
por: Fortunato, Orazio, et al.
Publicado: (2019)

Back to simplicity: a four-marker blood cell score to quantify prognostically relevant myeloid cells in melanoma patients
por: Huber, Veronica, et al.
Publicado: (2021)

More insights into the immunosuppressive potential of tumor exosomes
por: Huber, Veronica, et al.
Publicado: (2008)

Carbonic anhydrase versatility: from pH regulation to CO(2) sensing and metabolism
por: Supuran, Claudiu T.
Publicado: (2023)

Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies
por: Ferraroni, Marta, et al.
Publicado: (2022)

TLR3 Expression Induces Apoptosis in Human Non-Small-Cell Lung Cancer
por: Bianchi, Francesca, et al.
Publicado: (2020)

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
por: Bellone, Matteo, et al.
Publicado: (2013)

Nitric Oxide Donors and Selective Carbonic Anhydrase Inhibitors: A Dual Pharmacological Approach for the Treatment of Glaucoma, Cancer and Osteoporosis
por: Carradori, Simone, et al.
Publicado: (2015)

Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles
por: Andreola, Giovanna, et al.
Publicado: (2002)

Integrated transcriptional‐phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients
por: Rinchai, Darawan, et al.
Publicado: (2021)

Adaptive immune contexture at the tumour site and downmodulation of circulating myeloid-derived suppressor cells in the response of solitary fibrous tumour patients to anti-angiogenic therapy
por: Tazzari, M, et al.
Publicado: (2014)

Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori
por: Campestre, Cristina, et al.
Publicado: (2021)

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
por: Angeli, Andrea, et al.
Publicado: (2020)

Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators
por: Mollica, Adriano, et al.
Publicado: (2017)

Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators
por: Angeli, Andrea, et al.
Publicado: (2021)

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b
por: Vergani, Elisabetta, et al.
Publicado: (2015)

COVID-19 in long-term liver transplant patients: preliminary experience from an Italian transplant centre in Lombardy
por: Bhoori, Sherrie, et al.
Publicado: (2020)

Management of Dietary Habits and Diarrhea in Fap Individuals: A Mediterranean Low-Inflammatory Dietary Intervention
por: Maura, Ciniselli Chiara, et al.
Publicado: (2021)

miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators
por: Vergani, Elisabetta, et al.
Publicado: (2020)

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors
por: Güzel-Akdemir, Özlen, et al.
Publicado: (2020)

Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells
por: Liguori, Francesco, et al.
Publicado: (2022)

Intratumor Microbiome in Neuroendocrine Neoplasms: A New Partner of Tumor Microenvironment? A Pilot Study
por: Massironi, Sara, et al.
Publicado: (2022)

Metabolism and microenvironment in cancer plasticity
por: Baldini, Nicola, et al.
Publicado: (2016)

A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results
por: Pasanisi, Patrizia, et al.
Publicado: (2019)

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
por: Fortunato, Orazio, et al.
Publicado: (2022)

Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII
por: Fiorentino, Francesco, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fve7sno8vu0og9vkqej26ge05p