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Off and Back-On Again: A Tumor Suppressor’s Tale

Tumor suppressor genes play critical roles orchestrating anti-cancer programs that are both context dependent and mechanistically diverse. Beyond canonical tumor suppressive programs that control cell division, cell death, and genome stability, unexpected tumor suppressor gene activities that regula...

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Detalles Bibliográficos
Autores principales: Acosta, Jonuelle, Wang, Walter, Feldser, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993581/
https://www.ncbi.nlm.nih.gov/pubmed/29540833
http://dx.doi.org/10.1038/s41388-018-0186-3
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author Acosta, Jonuelle
Wang, Walter
Feldser, David M.
author_facet Acosta, Jonuelle
Wang, Walter
Feldser, David M.
author_sort Acosta, Jonuelle
collection PubMed
description Tumor suppressor genes play critical roles orchestrating anti-cancer programs that are both context dependent and mechanistically diverse. Beyond canonical tumor suppressive programs that control cell division, cell death, and genome stability, unexpected tumor suppressor gene activities that regulate metabolism, immune surveillance, the epigenetic landscape, and others have recently emerged. This diversity underscores the important roles these genes play in maintaining cellular homeostasis to suppress cancer initiation and progression, but also highlights a tremendous challenge in discerning precise context-specific programs of tumor suppression controlled by a given tumor suppressor. Fortunately, the rapid sophistication of genetically engineered mouse models of cancer has begun to shed light on these context-dependent tumor suppressor activities. By using techniques that not only toggle ‘off’ tumor suppressor genes in nascent tumors, but also facilitate the timely restoration of gene function ‘back-on again’ in disease specific contexts, precise mechanisms of tumor suppression can be revealed in an unbiased manner. This review discusses the development and implementation of genetic systems designed to toggle tumor suppressor genes off and back-on again and their potential to uncover the tumor suppressor’s tale.
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spelling pubmed-59935812018-09-15 Off and Back-On Again: A Tumor Suppressor’s Tale Acosta, Jonuelle Wang, Walter Feldser, David M. Oncogene Article Tumor suppressor genes play critical roles orchestrating anti-cancer programs that are both context dependent and mechanistically diverse. Beyond canonical tumor suppressive programs that control cell division, cell death, and genome stability, unexpected tumor suppressor gene activities that regulate metabolism, immune surveillance, the epigenetic landscape, and others have recently emerged. This diversity underscores the important roles these genes play in maintaining cellular homeostasis to suppress cancer initiation and progression, but also highlights a tremendous challenge in discerning precise context-specific programs of tumor suppression controlled by a given tumor suppressor. Fortunately, the rapid sophistication of genetically engineered mouse models of cancer has begun to shed light on these context-dependent tumor suppressor activities. By using techniques that not only toggle ‘off’ tumor suppressor genes in nascent tumors, but also facilitate the timely restoration of gene function ‘back-on again’ in disease specific contexts, precise mechanisms of tumor suppression can be revealed in an unbiased manner. This review discusses the development and implementation of genetic systems designed to toggle tumor suppressor genes off and back-on again and their potential to uncover the tumor suppressor’s tale. 2018-03-15 2018-06 /pmc/articles/PMC5993581/ /pubmed/29540833 http://dx.doi.org/10.1038/s41388-018-0186-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Acosta, Jonuelle
Wang, Walter
Feldser, David M.
Off and Back-On Again: A Tumor Suppressor’s Tale
title Off and Back-On Again: A Tumor Suppressor’s Tale
title_full Off and Back-On Again: A Tumor Suppressor’s Tale
title_fullStr Off and Back-On Again: A Tumor Suppressor’s Tale
title_full_unstemmed Off and Back-On Again: A Tumor Suppressor’s Tale
title_short Off and Back-On Again: A Tumor Suppressor’s Tale
title_sort off and back-on again: a tumor suppressor’s tale
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993581/
https://www.ncbi.nlm.nih.gov/pubmed/29540833
http://dx.doi.org/10.1038/s41388-018-0186-3
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