Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary disease (COPD) exacerbations and increase pneumonia risk, through unknown mechanisms. Rhinoviruses precipitate most exacerbations and increase susceptibility to secondary bacterial infections. Here, we show...

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Detalles Bibliográficos
Autores principales: Singanayagam, Aran, Glanville, Nicholas, Girkin, Jason L., Ching, Yee Man, Marcellini, Andrea, Porter, James D., Toussaint, Marie, Walton, Ross P., Finney, Lydia J., Aniscenko, Julia, Zhu, Jie, Trujillo-Torralbo, Maria-Belen, Calderazzo, Maria Adelaide, Grainge, Chris, Loo, Su-Ling, Veerati, Punnam Chander, Pathinayake, Prabuddha S., Nichol, Kristy S., Reid, Andrew T., James, Phillip L., Solari, Roberto, Wark, Peter A. B., Knight, Darryl A., Moffatt, Miriam F., Cookson, William O., Edwards, Michael R., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993715/
https://www.ncbi.nlm.nih.gov/pubmed/29884817
http://dx.doi.org/10.1038/s41467-018-04574-1

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