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Individuality and convergence of the infant gut microbiota during the first year of life
The human gut microbiota plays a vital role in health and disease, and microbial colonization is a key process in infant development. Here, we analyze 2684 fecal specimens from 12 infants during their first year of life, providing detailed insights into the human gut colonization process. Maturation...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993781/ https://www.ncbi.nlm.nih.gov/pubmed/29884786 http://dx.doi.org/10.1038/s41467-018-04641-7 |
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author | de Muinck, Eric J. Trosvik, Pål |
author_facet | de Muinck, Eric J. Trosvik, Pål |
author_sort | de Muinck, Eric J. |
collection | PubMed |
description | The human gut microbiota plays a vital role in health and disease, and microbial colonization is a key process in infant development. Here, we analyze 2684 fecal specimens from 12 infants during their first year of life, providing detailed insights into the human gut colonization process. Maturation of the gut microbial community shows strong temporal structure and specific developmental stages. At 2–4 months of age, there is a period of accelerated convergence concurrent with a bloom of Bifidobacterium, a genus associated with metabolism of oligosaccharides found in breast milk. The end of this period coincides with the introduction of solid food, a reduction in the relative abundance of Bifidobacterium, and an increase in several groups of Firmicutes. Our findings highlight the dynamic nature and individuality of the gut colonization process, and the need for high-frequency sampling over an extended period when designing and interpreting infant microbiome studies. |
format | Online Article Text |
id | pubmed-5993781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59937812018-06-11 Individuality and convergence of the infant gut microbiota during the first year of life de Muinck, Eric J. Trosvik, Pål Nat Commun Article The human gut microbiota plays a vital role in health and disease, and microbial colonization is a key process in infant development. Here, we analyze 2684 fecal specimens from 12 infants during their first year of life, providing detailed insights into the human gut colonization process. Maturation of the gut microbial community shows strong temporal structure and specific developmental stages. At 2–4 months of age, there is a period of accelerated convergence concurrent with a bloom of Bifidobacterium, a genus associated with metabolism of oligosaccharides found in breast milk. The end of this period coincides with the introduction of solid food, a reduction in the relative abundance of Bifidobacterium, and an increase in several groups of Firmicutes. Our findings highlight the dynamic nature and individuality of the gut colonization process, and the need for high-frequency sampling over an extended period when designing and interpreting infant microbiome studies. Nature Publishing Group UK 2018-06-08 /pmc/articles/PMC5993781/ /pubmed/29884786 http://dx.doi.org/10.1038/s41467-018-04641-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article de Muinck, Eric J. Trosvik, Pål Individuality and convergence of the infant gut microbiota during the first year of life |
title | Individuality and convergence of the infant gut microbiota during the first year of life |
title_full | Individuality and convergence of the infant gut microbiota during the first year of life |
title_fullStr | Individuality and convergence of the infant gut microbiota during the first year of life |
title_full_unstemmed | Individuality and convergence of the infant gut microbiota during the first year of life |
title_short | Individuality and convergence of the infant gut microbiota during the first year of life |
title_sort | individuality and convergence of the infant gut microbiota during the first year of life |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993781/ https://www.ncbi.nlm.nih.gov/pubmed/29884786 http://dx.doi.org/10.1038/s41467-018-04641-7 |
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