Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism

N(6)-methyladenosine (m(6)A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m(6)A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of...

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Detalles Bibliográficos
Autores principales: Yang, Ying, Hsu, Phillip J., Chen, Yu-Sheng, Yang, Yun-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993786/
https://www.ncbi.nlm.nih.gov/pubmed/29789545
http://dx.doi.org/10.1038/s41422-018-0040-8
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author Yang, Ying
Hsu, Phillip J.
Chen, Yu-Sheng
Yang, Yun-Gui
author_facet Yang, Ying
Hsu, Phillip J.
Chen, Yu-Sheng
Yang, Yun-Gui
author_sort Yang, Ying
collection PubMed
description N(6)-methyladenosine (m(6)A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m(6)A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m(6)A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.
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spelling pubmed-59937862018-06-20 Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism Yang, Ying Hsu, Phillip J. Chen, Yu-Sheng Yang, Yun-Gui Cell Res Review Article N(6)-methyladenosine (m(6)A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m(6)A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m(6)A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs. Nature Publishing Group UK 2018-05-22 2018-06 /pmc/articles/PMC5993786/ /pubmed/29789545 http://dx.doi.org/10.1038/s41422-018-0040-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Yang, Ying
Hsu, Phillip J.
Chen, Yu-Sheng
Yang, Yun-Gui
Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
title Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
title_full Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
title_fullStr Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
title_full_unstemmed Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
title_short Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
title_sort dynamic transcriptomic m(6)a decoration: writers, erasers, readers and functions in rna metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993786/
https://www.ncbi.nlm.nih.gov/pubmed/29789545
http://dx.doi.org/10.1038/s41422-018-0040-8
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