Whole Exome Sequencing of Patients from Multicase Families with Systemic Lupus Erythematosus Identifies Multiple Rare Variants

In an effort to identify rare alleles associated with SLE, we have performed whole exome sequencing of the most distantly related affected individuals from two large Icelandic multicase SLE families followed by Ta targeted genotyping of additional relatives. We identified multiple rare likely pathog...

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Detalles Bibliográficos
Autores principales: Delgado-Vega, Angélica M., Martínez-Bueno, Manuel, Oparina, Nina Y., López Herráez, David, Kristjansdottir, Helga, Steinsson, Kristján, Kozyrev, Sergey V., Alarcón-Riquelme, Marta E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993790/
https://www.ncbi.nlm.nih.gov/pubmed/29884787
http://dx.doi.org/10.1038/s41598-018-26274-y

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