Cargando…
Identification of serpins specific for activated protein C using a lysate-based screening assay
Activated protein C (APC) is a powerful anticoagulant enzyme that proteolytically inactivates the cofactors of the Xase and prothrombinase complexes, factors VIIIa and Va. A common mutation in factor V, fV(Leiden), confers resistance to APC leading to an increased risk of thrombosis in the normal po...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993791/ https://www.ncbi.nlm.nih.gov/pubmed/29884816 http://dx.doi.org/10.1038/s41598-018-27067-z |