Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins

Mutations in multiple RNA/DNA binding proteins cause Amyotrophic Lateral Sclerosis (ALS). Included among these are the three members of the FET family (FUS, EWSR1 and TAF15) and the structurally similar MATR3. Here, we characterized the interactomes of these four proteins, revealing that they largel...

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Detalles Bibliográficos
Autores principales: Chi, Binkai, O’Connell, Jeremy D., Yamazaki, Tomohiro, Gangopadhyay, Jaya, Gygi, Steven P., Reed, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993797/
https://www.ncbi.nlm.nih.gov/pubmed/29884807
http://dx.doi.org/10.1038/s41598-018-27136-3

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