Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

SAMHD1 is a critical restriction factor for HIV-1 in non-cycling cells and its antiviral activity is regulated by T592 phosphorylation. Here, we show that SAMHD1 dephosphorylation at T592 is controlled during the cell cycle, occurring during M/G(1) transition in proliferating cells. Using several co...

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Detalles Bibliográficos
Autores principales: Schott, Kerstin, Fuchs, Nina V., Derua, Rita, Mahboubi, Bijan, Schnellbächer, Esther, Seifried, Janna, Tondera, Christiane, Schmitz, Heike, Shepard, Caitlin, Brandariz-Nuñez, Alberto, Diaz-Griffero, Felipe, Reuter, Andreas, Kim, Baek, Janssens, Veerle, König, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993806/
https://www.ncbi.nlm.nih.gov/pubmed/29884836
http://dx.doi.org/10.1038/s41467-018-04671-1

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