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The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder()
INTRODUCTION: People with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes. This risk is greatly compounded by tobacco smoking, which is highly prevalent among people with chronic opioid use...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993889/ https://www.ncbi.nlm.nih.gov/pubmed/29892701 http://dx.doi.org/10.1016/j.abrep.2018.03.005 |
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author | Palis, Heather Marchand, Kirsten Karamouzian, Mohammad MacDonald, Scott Harrison, Scott Guh, Daphne Lock, Kurt Brissette, Suzanne Anis, Aslam H. Krausz, Michael Marsh, David C. Schechter, Martin T. Oviedo-Joekes, Eugenia |
author_facet | Palis, Heather Marchand, Kirsten Karamouzian, Mohammad MacDonald, Scott Harrison, Scott Guh, Daphne Lock, Kurt Brissette, Suzanne Anis, Aslam H. Krausz, Michael Marsh, David C. Schechter, Martin T. Oviedo-Joekes, Eugenia |
author_sort | Palis, Heather |
collection | PubMed |
description | INTRODUCTION: People with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes. This risk is greatly compounded by tobacco smoking, which is highly prevalent among people with chronic opioid use disorder. Despite the known burden of tobacco smoking on health, the relationship between nicotine dependence and health has not been studied among those receiving injectable opioid agonist treatment. As such, the present study aims to explore the association between nicotine dependence and physical health among participants of the Study to Assess Longer-Term Opioid Medication Effectiveness (SALOME) at baseline and six-months. METHODS: SALOME was a double-blind phase III clinical trial testing the non-inferiority of injectable hydromorphone to injectable diacetylmorphine for chronic opioid use disorder. Participants reporting tobacco smoking were included in a linear regression analysis of physical health at baseline (before receiving treatment) and at six-months. RESULTS: At baseline, nicotine dependence score, lifetime history of emotional, physical, or sexual abuse and prior month safe injection site access were independently and significantly associated with physical health. At six-months nicotine dependence score was the only variable that maintained this significant and independent association with physical health. CONCLUSIONS: Findings indicate that after six-months, the injectable treatment effectively brought equity to patients' physical health status, yet the association with nicotine dependence remained. Findings could inform whether the provision of treatment for nicotine dependence should be made a priority in settings where injectable opioid agonist treatment is delivered to achieve improvements in overall physical health in this population. |
format | Online Article Text |
id | pubmed-5993889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59938892018-06-11 The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() Palis, Heather Marchand, Kirsten Karamouzian, Mohammad MacDonald, Scott Harrison, Scott Guh, Daphne Lock, Kurt Brissette, Suzanne Anis, Aslam H. Krausz, Michael Marsh, David C. Schechter, Martin T. Oviedo-Joekes, Eugenia Addict Behav Rep Research paper INTRODUCTION: People with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes. This risk is greatly compounded by tobacco smoking, which is highly prevalent among people with chronic opioid use disorder. Despite the known burden of tobacco smoking on health, the relationship between nicotine dependence and health has not been studied among those receiving injectable opioid agonist treatment. As such, the present study aims to explore the association between nicotine dependence and physical health among participants of the Study to Assess Longer-Term Opioid Medication Effectiveness (SALOME) at baseline and six-months. METHODS: SALOME was a double-blind phase III clinical trial testing the non-inferiority of injectable hydromorphone to injectable diacetylmorphine for chronic opioid use disorder. Participants reporting tobacco smoking were included in a linear regression analysis of physical health at baseline (before receiving treatment) and at six-months. RESULTS: At baseline, nicotine dependence score, lifetime history of emotional, physical, or sexual abuse and prior month safe injection site access were independently and significantly associated with physical health. At six-months nicotine dependence score was the only variable that maintained this significant and independent association with physical health. CONCLUSIONS: Findings indicate that after six-months, the injectable treatment effectively brought equity to patients' physical health status, yet the association with nicotine dependence remained. Findings could inform whether the provision of treatment for nicotine dependence should be made a priority in settings where injectable opioid agonist treatment is delivered to achieve improvements in overall physical health in this population. Elsevier 2018-03-27 /pmc/articles/PMC5993889/ /pubmed/29892701 http://dx.doi.org/10.1016/j.abrep.2018.03.005 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research paper Palis, Heather Marchand, Kirsten Karamouzian, Mohammad MacDonald, Scott Harrison, Scott Guh, Daphne Lock, Kurt Brissette, Suzanne Anis, Aslam H. Krausz, Michael Marsh, David C. Schechter, Martin T. Oviedo-Joekes, Eugenia The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
title | The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
title_full | The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
title_fullStr | The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
title_full_unstemmed | The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
title_short | The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
title_sort | association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder() |
topic | Research paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993889/ https://www.ncbi.nlm.nih.gov/pubmed/29892701 http://dx.doi.org/10.1016/j.abrep.2018.03.005 |
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