Conditional Regulation of Gene Expression by Ligand-Induced Occlusion of a MicroRNA Target Sequence

RNA switches that modulate gene expression with small molecules have a number of scientific and clinical applications. Here, we describe a novel class of small regulatory on switches based on the ability of a ligand-bound aptamer to promote stem formation between a microRNA target sequence (miR-T) a...

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Detalles Bibliográficos
Autores principales: Mou, Huihui, Zhong, Guocai, Gardner, Matthew R., Wang, Haimin, Wang, Yi-Wen, Cheng, Dechun, Farzan, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993935/
https://www.ncbi.nlm.nih.gov/pubmed/29567311
http://dx.doi.org/10.1016/j.ymthe.2018.02.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993935/
https://www.ncbi.nlm.nih.gov/pubmed/29567311
http://dx.doi.org/10.1016/j.ymthe.2018.02.021

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