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Conditional Regulation of Gene Expression by Ligand-Induced Occlusion of a MicroRNA Target Sequence
RNA switches that modulate gene expression with small molecules have a number of scientific and clinical applications. Here, we describe a novel class of small regulatory on switches based on the ability of a ligand-bound aptamer to promote stem formation between a microRNA target sequence (miR-T) a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993935/ https://www.ncbi.nlm.nih.gov/pubmed/29567311 http://dx.doi.org/10.1016/j.ymthe.2018.02.021 |