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Effect of the 5-HT(4) receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract
OBJECTIVE: Tegaserod is a 5-hydroxytryptamine type 4 (5-HT(4)) receptor agonist, formerly used in treating constipation predominant irritable bowel syndrome, which desensitizes 5-HT(4) receptors in rat oesophagus and colon in vitro. Desensitization of 5-HT(4) receptors is regulated by G-protein coup...
Autores principales: | Nedi, Teshome, White, Paul J., Coupar, Ian M., Irving, Helen R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994065/ https://www.ncbi.nlm.nih.gov/pubmed/29884229 http://dx.doi.org/10.1186/s13104-018-3495-2 |
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