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A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats
BACKGROUND: Domestic cats play a key role in the epidemiology of the parasite Toxoplasma gondii by excreting environmentally-resistant oocysts that may infect humans and other warm-blooded animals. The dynamics of Toxoplasma gondii seroconversion, used as a proxy for primo-infection dynamics, was in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994099/ https://www.ncbi.nlm.nih.gov/pubmed/29884240 http://dx.doi.org/10.1186/s13071-018-2834-4 |
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author | Simon, Julie Alice Pradel, Roger Aubert, Dominique Geers, Régine Villena, Isabelle Poulle, Marie-Lazarine |
author_facet | Simon, Julie Alice Pradel, Roger Aubert, Dominique Geers, Régine Villena, Isabelle Poulle, Marie-Lazarine |
author_sort | Simon, Julie Alice |
collection | PubMed |
description | BACKGROUND: Domestic cats play a key role in the epidemiology of the parasite Toxoplasma gondii by excreting environmentally-resistant oocysts that may infect humans and other warm-blooded animals. The dynamics of Toxoplasma gondii seroconversion, used as a proxy for primo-infection dynamics, was investigated in five cat populations living on farms. METHODS: Serological tests on blood samples from cats were performed every three months over a period of two years, for a total of 400 serological tests performed on 130 cats. Variations in seroconversion rates and associated factors were investigated using a multi-event capture-recapture modelling approach that explicitly accounted for uncertainties in cat age and serological status. RESULTS: Seroprevalence varied between farms, from 15 to 73%, suggesting differential exposure of cats to T. gondii. In farms with high exposure, cats could become infected before reaching the age of six months. Seroconversion rates varied from 0.42 to 0.96 seroconversions per cat per year and were higher in autumn and winter than in spring and summer. CONCLUSION: Our results suggest inter-farm and seasonal variations in the risks of exposure to T. gondii oocysts for humans and livestock living on farms. The paper also discusses the role of young cats in the maintenance of environmental contamination by T. gondii oocysts on farms. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13071-018-2834-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5994099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59940992018-06-21 A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats Simon, Julie Alice Pradel, Roger Aubert, Dominique Geers, Régine Villena, Isabelle Poulle, Marie-Lazarine Parasit Vectors Research BACKGROUND: Domestic cats play a key role in the epidemiology of the parasite Toxoplasma gondii by excreting environmentally-resistant oocysts that may infect humans and other warm-blooded animals. The dynamics of Toxoplasma gondii seroconversion, used as a proxy for primo-infection dynamics, was investigated in five cat populations living on farms. METHODS: Serological tests on blood samples from cats were performed every three months over a period of two years, for a total of 400 serological tests performed on 130 cats. Variations in seroconversion rates and associated factors were investigated using a multi-event capture-recapture modelling approach that explicitly accounted for uncertainties in cat age and serological status. RESULTS: Seroprevalence varied between farms, from 15 to 73%, suggesting differential exposure of cats to T. gondii. In farms with high exposure, cats could become infected before reaching the age of six months. Seroconversion rates varied from 0.42 to 0.96 seroconversions per cat per year and were higher in autumn and winter than in spring and summer. CONCLUSION: Our results suggest inter-farm and seasonal variations in the risks of exposure to T. gondii oocysts for humans and livestock living on farms. The paper also discusses the role of young cats in the maintenance of environmental contamination by T. gondii oocysts on farms. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13071-018-2834-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-08 /pmc/articles/PMC5994099/ /pubmed/29884240 http://dx.doi.org/10.1186/s13071-018-2834-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Simon, Julie Alice Pradel, Roger Aubert, Dominique Geers, Régine Villena, Isabelle Poulle, Marie-Lazarine A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats |
title | A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats |
title_full | A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats |
title_fullStr | A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats |
title_full_unstemmed | A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats |
title_short | A multi-event capture-recapture analysis of Toxoplasma gondii seroconversion dynamics in farm cats |
title_sort | multi-event capture-recapture analysis of toxoplasma gondii seroconversion dynamics in farm cats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994099/ https://www.ncbi.nlm.nih.gov/pubmed/29884240 http://dx.doi.org/10.1186/s13071-018-2834-4 |
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