Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2(G2019S)-Parkinson’s disease

BACKGROUND: Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autoph...

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Detalles Bibliográficos
Autores principales: Juárez-Flores, Diana Luz, González-Casacuberta, Ingrid, Ezquerra, Mario, Bañó, María, Carmona-Pontaque, Francesc, Catalán-García, Marc, Guitart-Mampel, Mariona, Rivero, Juan José, Tobias, Ester, Milisenda, Jose Cesar, Tolosa, Eduard, Marti, Maria Jose, Fernández-Santiago, Ruben, Cardellach, Francesc, Morén, Constanza, Garrabou, Glòria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994110/
https://www.ncbi.nlm.nih.gov/pubmed/29884186
http://dx.doi.org/10.1186/s12967-018-1526-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994110/
https://www.ncbi.nlm.nih.gov/pubmed/29884186
http://dx.doi.org/10.1186/s12967-018-1526-3

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