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Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan

OBJECTIVE: Monitoring tuberculosis treatment outcomes and understanding the reasons for unsuccessful treatment are important indicators for evaluating the performance of the national tuberculosis control program. The aim of this study was to evaluate the treatment outcomes among pulmonary TB (PTB) p...

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Autores principales: Atif, Muhammad, Anwar, Zainab, Fatima, Razia Kaneez, Malik, Iram, Asghar, Saima, Scahill, Shane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994136/
https://www.ncbi.nlm.nih.gov/pubmed/29884241
http://dx.doi.org/10.1186/s13104-018-3473-8
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author Atif, Muhammad
Anwar, Zainab
Fatima, Razia Kaneez
Malik, Iram
Asghar, Saima
Scahill, Shane
author_facet Atif, Muhammad
Anwar, Zainab
Fatima, Razia Kaneez
Malik, Iram
Asghar, Saima
Scahill, Shane
author_sort Atif, Muhammad
collection PubMed
description OBJECTIVE: Monitoring tuberculosis treatment outcomes and understanding the reasons for unsuccessful treatment are important indicators for evaluating the performance of the national tuberculosis control program. The aim of this study was to evaluate the treatment outcomes among pulmonary TB (PTB) patients and identify the predictors of unsuccessful treatment outcome. RESULTS: Treatment success rate of 67.8% among new and retreatment PTB patients and 69% in new smear positive PTB patients was observed. Close to 21% (20.9%) and 15.7% PTB and new smear positive PTB patients had loss to follow-up during treatment. Overall, older patients (AOR 1.02; 95% CI 1.01–1.0), smokers (AOR 1.65; 95% CI 1.02–2.67) and retreatment cases of TB (AOR 2.34; 95% CI 1.43–3.84) were at greater risk of having unsuccessful treatment outcomes. Moreover, sputum positivity at 2 months (AOR 13.78; 95% CI 5.09–37.26) was a significant predictor of poor treatment outcomes in new smear positive PTB patients. The treatment success rate among PTB patients was lower than the recommended 85% success rate. TB patients at higher risk of unsuccessful treatment outcomes should be provided with enhanced supervision and treatment monitoring to improve the success rate of TB management in Pakistan. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3473-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-59941362018-06-21 Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan Atif, Muhammad Anwar, Zainab Fatima, Razia Kaneez Malik, Iram Asghar, Saima Scahill, Shane BMC Res Notes Research Note OBJECTIVE: Monitoring tuberculosis treatment outcomes and understanding the reasons for unsuccessful treatment are important indicators for evaluating the performance of the national tuberculosis control program. The aim of this study was to evaluate the treatment outcomes among pulmonary TB (PTB) patients and identify the predictors of unsuccessful treatment outcome. RESULTS: Treatment success rate of 67.8% among new and retreatment PTB patients and 69% in new smear positive PTB patients was observed. Close to 21% (20.9%) and 15.7% PTB and new smear positive PTB patients had loss to follow-up during treatment. Overall, older patients (AOR 1.02; 95% CI 1.01–1.0), smokers (AOR 1.65; 95% CI 1.02–2.67) and retreatment cases of TB (AOR 2.34; 95% CI 1.43–3.84) were at greater risk of having unsuccessful treatment outcomes. Moreover, sputum positivity at 2 months (AOR 13.78; 95% CI 5.09–37.26) was a significant predictor of poor treatment outcomes in new smear positive PTB patients. The treatment success rate among PTB patients was lower than the recommended 85% success rate. TB patients at higher risk of unsuccessful treatment outcomes should be provided with enhanced supervision and treatment monitoring to improve the success rate of TB management in Pakistan. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3473-8) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-08 /pmc/articles/PMC5994136/ /pubmed/29884241 http://dx.doi.org/10.1186/s13104-018-3473-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Atif, Muhammad
Anwar, Zainab
Fatima, Razia Kaneez
Malik, Iram
Asghar, Saima
Scahill, Shane
Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan
title Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan
title_full Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan
title_fullStr Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan
title_full_unstemmed Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan
title_short Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan
title_sort analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in bahawalpur, pakistan
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994136/
https://www.ncbi.nlm.nih.gov/pubmed/29884241
http://dx.doi.org/10.1186/s13104-018-3473-8
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