Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

CDKL5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 (cyclin-dependent kinase-like five) gene. CDKL5 disorder primarily affects girls and is characterized by early-onset epileptic seizures, gross motor impairment, intellectual disability, and autistic feat...

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Detalles Bibliográficos
Autores principales: Fuchs, Claudia, Gennaccaro, Laura, Trazzi, Stefania, Bastianini, Stefano, Bettini, Simone, Lo Martire, Viviana, Ren, Elisa, Medici, Giorgio, Zoccoli, Giovanna, Rimondini, Roberto, Ciani, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994305/
https://www.ncbi.nlm.nih.gov/pubmed/29977282
http://dx.doi.org/10.1155/2018/9726950

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