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Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions
Burkholderia pseudomallei is a Gram-negative bacterium that causes melioidosis, which can be fatal in humans. Melioidosis is prevalent in the tropical regions of Southeast Asia and Northern Australia. Ecological data have shown that this bacterium can survive as a free-living organism in environment...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994319/ https://www.ncbi.nlm.nih.gov/pubmed/29992136 http://dx.doi.org/10.1155/2018/3039106 |
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author | Duangurai, Taksaon Indrawattana, Nitaya Pumirat, Pornpan |
author_facet | Duangurai, Taksaon Indrawattana, Nitaya Pumirat, Pornpan |
author_sort | Duangurai, Taksaon |
collection | PubMed |
description | Burkholderia pseudomallei is a Gram-negative bacterium that causes melioidosis, which can be fatal in humans. Melioidosis is prevalent in the tropical regions of Southeast Asia and Northern Australia. Ecological data have shown that this bacterium can survive as a free-living organism in environmental niches, such as soil and water, as well as a parasite living in host organisms, such as ameba, plants, fungi, and animals. This review provides an overview of the survival and adaptation of B. pseudomallei to stressful conditions induced by hostile environmental factors, such as salinity, oxidation, and iron levels. The adaptation of B. pseudomallei in host cells is also reviewed. The adaptive survival mechanisms of this pathogen mainly involve modulation of gene and protein expression, which could cause alterations in the bacteria's cell membrane, metabolism, and virulence. Understanding the adaptations of this organism to environmental factors provides important insights into the survival and pathogenesis of B. pseudomallei, which may lead to the development of novel strategies for the control, prevention, and treatment of melioidosis in the future. |
format | Online Article Text |
id | pubmed-5994319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59943192018-07-10 Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions Duangurai, Taksaon Indrawattana, Nitaya Pumirat, Pornpan Biomed Res Int Review Article Burkholderia pseudomallei is a Gram-negative bacterium that causes melioidosis, which can be fatal in humans. Melioidosis is prevalent in the tropical regions of Southeast Asia and Northern Australia. Ecological data have shown that this bacterium can survive as a free-living organism in environmental niches, such as soil and water, as well as a parasite living in host organisms, such as ameba, plants, fungi, and animals. This review provides an overview of the survival and adaptation of B. pseudomallei to stressful conditions induced by hostile environmental factors, such as salinity, oxidation, and iron levels. The adaptation of B. pseudomallei in host cells is also reviewed. The adaptive survival mechanisms of this pathogen mainly involve modulation of gene and protein expression, which could cause alterations in the bacteria's cell membrane, metabolism, and virulence. Understanding the adaptations of this organism to environmental factors provides important insights into the survival and pathogenesis of B. pseudomallei, which may lead to the development of novel strategies for the control, prevention, and treatment of melioidosis in the future. Hindawi 2018-05-27 /pmc/articles/PMC5994319/ /pubmed/29992136 http://dx.doi.org/10.1155/2018/3039106 Text en Copyright © 2018 Taksaon Duangurai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Duangurai, Taksaon Indrawattana, Nitaya Pumirat, Pornpan Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions |
title |
Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions |
title_full |
Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions |
title_fullStr |
Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions |
title_full_unstemmed |
Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions |
title_short |
Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions |
title_sort | burkholderia pseudomallei adaptation for survival in stressful conditions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994319/ https://www.ncbi.nlm.nih.gov/pubmed/29992136 http://dx.doi.org/10.1155/2018/3039106 |
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