CD8(+)HLADR(+) Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

CD4(+) regulatory T cells have been intensively studied during aging, but little is still known about age-related changes of other regulatory T cell subsets. It was, therefore, the goal of the present study to analyze CD8(+)human leukocyte antigen–antigen D related (HLADR)(+) T cells in old age, a c...

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Detalles Bibliográficos
Autores principales: Lukas Yani, Stella, Keller, Michael, Melzer, Franz Leonard, Weinberger, Birgit, Pangrazzi, Luca, Sopper, Sieghart, Trieb, Klemens, Lobina, Monia, Orrù, Valeria, Fiorillo, Edoardo, Cucca, Francesco, Grubeck-Loebenstein, Beatrix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994398/
https://www.ncbi.nlm.nih.gov/pubmed/29915580
http://dx.doi.org/10.3389/fimmu.2018.01201

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