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Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study

The healing potential of knee osteochondritis dissecans (OCD) focal lesions is not well defined. We performed a cross-sectional study correlating local and systemic biological characteristics with the patients' characteristics. We evaluated both local tissue markers (CD34, CD146, CD166, and tar...

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Autores principales: Gabusi, Elena, Manferdini, Cristina, Paolella, Francesca, Gambari, Laura, Kon, Elizaveta, Filardo, Giuseppe, Mariani, Erminia, Lisignoli, Gina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994568/
https://www.ncbi.nlm.nih.gov/pubmed/29998134
http://dx.doi.org/10.1155/2018/5458704
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author Gabusi, Elena
Manferdini, Cristina
Paolella, Francesca
Gambari, Laura
Kon, Elizaveta
Filardo, Giuseppe
Mariani, Erminia
Lisignoli, Gina
author_facet Gabusi, Elena
Manferdini, Cristina
Paolella, Francesca
Gambari, Laura
Kon, Elizaveta
Filardo, Giuseppe
Mariani, Erminia
Lisignoli, Gina
author_sort Gabusi, Elena
collection PubMed
description The healing potential of knee osteochondritis dissecans (OCD) focal lesions is not well defined. We performed a cross-sectional study correlating local and systemic biological characteristics with the patients' characteristics. We evaluated both local tissue markers (CD34, CD146, CD166, and tartrate-resistant acid phosphatase (TRAP)) and systemic serum biomarkers (fragments or propeptide of type II collagen: C2C, CTX-II, CPII, and TRAP5b) on histologically scored osteochondral fragments or serum from OCD patients. These biological features were associated with the patients' characteristics (IKDC subjective score, age, and body mass index (BMI)). Histological cartilage tissue score correlated with patients' IKDC and C2C and CPII biomarkers. CPII correlated also with histological bone tissue score. The percentage of CD146 positive cells in cartilage and CD34 positive cells in bone highly correlated with the patient's age and BMI, respectively. The percentage of TRAP in bone was directly correlated with both IKDC and age. Multivariate statistical analysis evidenced that only four parameters significantly predicted IKDC. In conclusion, a complete picture of OCD knee characteristics, defined by local and systemic markers of cartilage and bone remodeling, together with the patients' characteristics, might help to better understand the healing potential of each patient and to target and improve current OCD treatments.
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spelling pubmed-59945682018-07-11 Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study Gabusi, Elena Manferdini, Cristina Paolella, Francesca Gambari, Laura Kon, Elizaveta Filardo, Giuseppe Mariani, Erminia Lisignoli, Gina Biomed Res Int Research Article The healing potential of knee osteochondritis dissecans (OCD) focal lesions is not well defined. We performed a cross-sectional study correlating local and systemic biological characteristics with the patients' characteristics. We evaluated both local tissue markers (CD34, CD146, CD166, and tartrate-resistant acid phosphatase (TRAP)) and systemic serum biomarkers (fragments or propeptide of type II collagen: C2C, CTX-II, CPII, and TRAP5b) on histologically scored osteochondral fragments or serum from OCD patients. These biological features were associated with the patients' characteristics (IKDC subjective score, age, and body mass index (BMI)). Histological cartilage tissue score correlated with patients' IKDC and C2C and CPII biomarkers. CPII correlated also with histological bone tissue score. The percentage of CD146 positive cells in cartilage and CD34 positive cells in bone highly correlated with the patient's age and BMI, respectively. The percentage of TRAP in bone was directly correlated with both IKDC and age. Multivariate statistical analysis evidenced that only four parameters significantly predicted IKDC. In conclusion, a complete picture of OCD knee characteristics, defined by local and systemic markers of cartilage and bone remodeling, together with the patients' characteristics, might help to better understand the healing potential of each patient and to target and improve current OCD treatments. Hindawi 2018-05-28 /pmc/articles/PMC5994568/ /pubmed/29998134 http://dx.doi.org/10.1155/2018/5458704 Text en Copyright © 2018 Elena Gabusi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gabusi, Elena
Manferdini, Cristina
Paolella, Francesca
Gambari, Laura
Kon, Elizaveta
Filardo, Giuseppe
Mariani, Erminia
Lisignoli, Gina
Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
title Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
title_full Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
title_fullStr Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
title_full_unstemmed Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
title_short Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study
title_sort clinical and biological signature of osteochondritis dissecans in a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994568/
https://www.ncbi.nlm.nih.gov/pubmed/29998134
http://dx.doi.org/10.1155/2018/5458704
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