Cargando…

Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression

Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and p...

Descripción completa

Detalles Bibliográficos
Autores principales: Cubillos-Zapata, Carolina, Hernández-Jiménez, Enrique, Avendaño-Ortiz, José, Toledano, Victor, Varela-Serrano, Anibal, Fernández-Navarro, Isabel, Casitas, Raquel, Carpio, Carlos, Aguirre, Luis A., García-Río, Francisco, López-Collazo, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994578/
https://www.ncbi.nlm.nih.gov/pubmed/29997451
http://dx.doi.org/10.1155/2018/7373921
_version_ 1783330457467748352
author Cubillos-Zapata, Carolina
Hernández-Jiménez, Enrique
Avendaño-Ortiz, José
Toledano, Victor
Varela-Serrano, Anibal
Fernández-Navarro, Isabel
Casitas, Raquel
Carpio, Carlos
Aguirre, Luis A.
García-Río, Francisco
López-Collazo, Eduardo
author_facet Cubillos-Zapata, Carolina
Hernández-Jiménez, Enrique
Avendaño-Ortiz, José
Toledano, Victor
Varela-Serrano, Anibal
Fernández-Navarro, Isabel
Casitas, Raquel
Carpio, Carlos
Aguirre, Luis A.
García-Río, Francisco
López-Collazo, Eduardo
author_sort Cubillos-Zapata, Carolina
collection PubMed
description Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1α expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1α-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1α secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context.
format Online
Article
Text
id pubmed-5994578
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-59945782018-07-11 Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression Cubillos-Zapata, Carolina Hernández-Jiménez, Enrique Avendaño-Ortiz, José Toledano, Victor Varela-Serrano, Anibal Fernández-Navarro, Isabel Casitas, Raquel Carpio, Carlos Aguirre, Luis A. García-Río, Francisco López-Collazo, Eduardo Mediators Inflamm Research Article Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1α expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1α-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1α secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context. Hindawi 2018-05-28 /pmc/articles/PMC5994578/ /pubmed/29997451 http://dx.doi.org/10.1155/2018/7373921 Text en Copyright © 2018 Carolina Cubillos-Zapata et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cubillos-Zapata, Carolina
Hernández-Jiménez, Enrique
Avendaño-Ortiz, José
Toledano, Victor
Varela-Serrano, Anibal
Fernández-Navarro, Isabel
Casitas, Raquel
Carpio, Carlos
Aguirre, Luis A.
García-Río, Francisco
López-Collazo, Eduardo
Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
title Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
title_full Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
title_fullStr Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
title_full_unstemmed Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
title_short Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
title_sort obstructive sleep apnea monocytes exhibit high levels of vascular endothelial growth factor secretion, augmenting tumor progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994578/
https://www.ncbi.nlm.nih.gov/pubmed/29997451
http://dx.doi.org/10.1155/2018/7373921
work_keys_str_mv AT cubilloszapatacarolina obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT hernandezjimenezenrique obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT avendanoortizjose obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT toledanovictor obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT varelaserranoanibal obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT fernandeznavarroisabel obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT casitasraquel obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT carpiocarlos obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT aguirreluisa obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT garciariofrancisco obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression
AT lopezcollazoeduardo obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression