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Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

INTRODUCTION: Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely describe...

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Autores principales: De Moraes, C. Gustavo, Pettito, Michele, Yepez, Juan B., Sakuntabhai, Anavaj, Simon-Loriere, Etienne, Zaidi, Mussaret B., Prot, Matthieu, Ruffie, Claude, Kim, Susan S., Allikmets, Rando, Terwilliger, Joseph D., Lee, Joseph H., Maestre, Gladys E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994708/
https://www.ncbi.nlm.nih.gov/pubmed/29896405
http://dx.doi.org/10.1099/jmmcr.0.005145
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author De Moraes, C. Gustavo
Pettito, Michele
Yepez, Juan B.
Sakuntabhai, Anavaj
Simon-Loriere, Etienne
Zaidi, Mussaret B.
Prot, Matthieu
Ruffie, Claude
Kim, Susan S.
Allikmets, Rando
Terwilliger, Joseph D.
Lee, Joseph H.
Maestre, Gladys E.
author_facet De Moraes, C. Gustavo
Pettito, Michele
Yepez, Juan B.
Sakuntabhai, Anavaj
Simon-Loriere, Etienne
Zaidi, Mussaret B.
Prot, Matthieu
Ruffie, Claude
Kim, Susan S.
Allikmets, Rando
Terwilliger, Joseph D.
Lee, Joseph H.
Maestre, Gladys E.
author_sort De Moraes, C. Gustavo
collection PubMed
description INTRODUCTION: Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV). CASE PRESENTATION: One adult with bilateral optic neuritis, a child of 4 years of age with retrobulbar uveitis and a newborn with bilateral congenital glaucoma had a recent history of an acute exanthematous infection consistent with ZIKV infection. The results of ELISA tests indicated that all patients were seropositive for ZIKV and four DENV serotypes. CONCLUSION: Patients with ZIKV infection can develop severe ocular complications. Anti-DENV antibodies from previous infections could play a role in the pathogenesis of these complications. Well-designed epidemiological studies are urgently needed to measure the risk of ZIKV ocular complications and confirm whether they are associated with the presence of anti-flaviviral antibodies.
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spelling pubmed-59947082018-06-12 Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients De Moraes, C. Gustavo Pettito, Michele Yepez, Juan B. Sakuntabhai, Anavaj Simon-Loriere, Etienne Zaidi, Mussaret B. Prot, Matthieu Ruffie, Claude Kim, Susan S. Allikmets, Rando Terwilliger, Joseph D. Lee, Joseph H. Maestre, Gladys E. JMM Case Rep Case Series INTRODUCTION: Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV). CASE PRESENTATION: One adult with bilateral optic neuritis, a child of 4 years of age with retrobulbar uveitis and a newborn with bilateral congenital glaucoma had a recent history of an acute exanthematous infection consistent with ZIKV infection. The results of ELISA tests indicated that all patients were seropositive for ZIKV and four DENV serotypes. CONCLUSION: Patients with ZIKV infection can develop severe ocular complications. Anti-DENV antibodies from previous infections could play a role in the pathogenesis of these complications. Well-designed epidemiological studies are urgently needed to measure the risk of ZIKV ocular complications and confirm whether they are associated with the presence of anti-flaviviral antibodies. Microbiology Society 2018-03-14 /pmc/articles/PMC5994708/ /pubmed/29896405 http://dx.doi.org/10.1099/jmmcr.0.005145 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Series
De Moraes, C. Gustavo
Pettito, Michele
Yepez, Juan B.
Sakuntabhai, Anavaj
Simon-Loriere, Etienne
Zaidi, Mussaret B.
Prot, Matthieu
Ruffie, Claude
Kim, Susan S.
Allikmets, Rando
Terwilliger, Joseph D.
Lee, Joseph H.
Maestre, Gladys E.
Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
title Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
title_full Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
title_fullStr Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
title_full_unstemmed Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
title_short Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
title_sort optic neuropathy and congenital glaucoma associated with probable zika virus infection in venezuelan patients
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994708/
https://www.ncbi.nlm.nih.gov/pubmed/29896405
http://dx.doi.org/10.1099/jmmcr.0.005145
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