AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2

AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic activator of the protein kinase AMPK, the AICAR monophosphate derivative ZMP was also shown to mediate AMPK-independent effects. In order to unveil t...

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Detalles Bibliográficos
Autores principales: Philippe, Chloé, Pinson, Benoît, Dompierre, Jim, Pantesco, Véronique, Viollet, Benoît, Daignan-Fornier, Bertrand, Moenner, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994775/
https://www.ncbi.nlm.nih.gov/pubmed/29730476
http://dx.doi.org/10.1016/j.neo.2018.03.006

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