Cargando…

Alleviation of reactive oxygen species enhances PUFA accumulation in Schizochytrium sp. through regulating genes involved in lipid metabolism

The unicellular heterotrophic thraustochytrids are attractive candidates for commercial polyunsaturated fatty acids (PUFA) production. However, the reactive oxygen species (ROS) generated in their aerobic fermentation process often limits their PUFA titer. Yet, the specific mechanisms of ROS involve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Sai, He, Yaodong, Sen, Biswarup, Chen, Xiaohong, Xie, Yunxuan, Keasling, Jay D., Wang, Guangyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994804/ https://www.ncbi.nlm.nih.gov/pubmed/29896446 http://dx.doi.org/10.1016/j.meteno.2018.03.002

Ejemplares similares

Exogenous Antioxidants Improve the Accumulation of Saturated and Polyunsaturated Fatty Acids in Schizochytrium sp. PKU#Mn4
por: Zhang, Sai, et al.
Publicado: (2021)

Improved production of docosahexaenoic acid in batch fermentation by newly-isolated strains of Schizochytrium sp. and Thraustochytriidae sp. through bioprocess optimization
por: Wang, Qiuzhen, et al.
Publicado: (2018)

ARTP Mutagenesis of Schizochytrium sp. PKU#Mn4 and Clethodim-Based Mutant Screening for Enhanced Docosahexaenoic Acid Accumulation
por: Liu, Lu, et al.
Publicado: (2021)

Enhancing biomass and lipid accumulation in the microalgae Schizochytrium sp. by addition of fulvic acid and EDTA
por: Sun, Xiao-Man, et al.
Publicado: (2018)

New insights into phenotypic heterogeneity for the distinct lipid accumulation of Schizochytrium sp. H016
por: Bao, Zhendong, et al.
Publicado: (2022)

Culturable Diversity and Lipid Production Profile of Labyrinthulomycete Protists Isolated from Coastal Mangrove Habitats of China
por: Wang, Qiuzhen, et al.
Publicado: (2019)

Functions of Enyolreductase (ER) Domains of PKS Cluster in Lipid Synthesis and Enhancement of PUFAs Accumulation in Schizochytrium limacinum SR21 Using Triclosan as a Regulator of ER
por: Ling, Xueping, et al.
Publicado: (2020)

Optimal NaCl Medium Enhances Squalene Accumulation in Thraustochytrium sp. ATCC 26185 and Influences the Expression Levels of Key Metabolic Genes
por: Zhang, Aiqing, et al.
Publicado: (2022)

Transcriptome Analysis Reveals an Eicosapentaenoic Acid Accumulation Mechanism in a Schizochytrium sp. Mutant
por: Ou, Ying, et al.
Publicado: (2023)

Lipid Extraction from Spirulina sp. and Schizochytrium sp. Using Supercritical CO(2) with Methanol
por: Liu, Shihong, et al.
Publicado: (2018)

Nitrogen Starvation Enhances the Production of Saturated and Unsaturated Fatty Acids in Aurantiochytrium sp. PKU#SW8 by Regulating Key Biosynthetic Genes
por: Chen, Xiaohong, et al.
Publicado: (2022)

Transcriptomic Analysis of the Regulation of Lipid Fraction Migration and Fatty Acid Biosynthesis in Schizochytrium sp.
por: Ren, Lujing, et al.
Publicado: (2017)

Comparative analysis reveals unexpected genome features of newly isolated Thraustochytrids strains: on ecological function and PUFAs biosynthesis
por: Song, Zhiquan, et al.
Publicado: (2018)

Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines
por: Ramos-Vega, Abel, et al.
Publicado: (2018)

Development of an Efficient Gene Editing Tool in Schizochytrium sp. and Improving Its Lipid and Terpenoid Biosynthesis
por: Huang, Peng-Wei, et al.
Publicado: (2021)

Chemical and Physical Culture Conditions Significantly Influence the Cell Mass and Docosahexaenoic Acid Content of Aurantiochytrium limacinum Strain PKU#SW8
por: Chen, Xiaohong, et al.
Publicado: (2021)

Engineering the xylose metabolism in Schizochytrium sp. to improve the utilization of lignocellulose
por: Wang, Ling-Ru, et al.
Publicado: (2022)

Genome Sequence of Schizochytrium sp. CCTCC M209059, an Effective Producer of Docosahexaenoic Acid-Rich Lipids
por: Ji, Xiao-Jun, et al.
Publicado: (2015)

Schizochytrium sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells
por: Zeng, Zuye, et al.
Publicado: (2023)

Transcriptome and gene expression analysis of docosahexaenoic acid producer Schizochytrium sp. under different oxygen supply conditions
por: Bi, Zhi-Qian, et al.
Publicado: (2018)

Development of a cooperative two-factor adaptive-evolution method to enhance lipid production and prevent lipid peroxidation in Schizochytrium sp.
por: Sun, Xiao-Man, et al.
Publicado: (2018)

Saturated and Polyunsaturated Fatty Acids Production by Aurantiochytrium limacinum PKU#Mn4 on Enteromorpha Hydrolysate
por: He, Yaodong, et al.
Publicado: (2023)

Screening chemical modulators of benzoic acid derivatives to improve lipid accumulation in Schizochytrium limacinum SR21 with metabolomics analysis
por: Li, Zhipeng, et al.
Publicado: (2019)

Metabolite profiling of Schizochytrium sp. by GC-MS, an oleaginous microbial source of biodiesel
por: Mioso, Roberto, et al.
Publicado: (2014)

Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation
por: Wang, Xiaoli, et al.
Publicado: (2018)

Freshwater microalgae (Schizochytrium sp.) as a substitute to fish oil for shrimp feed
por: Allen, Kristy M., et al.
Publicado: (2019)

Simultaneous DHA and organic selenium production by Schizochytrium sp.: a theoretical basis
por: Zhang, Yunqiang, et al.
Publicado: (2023)

Lipid Production of Schizochytrium sp. HBW10 Isolated from Coastal Waters of Northern China Cultivated in Food Waste Hydrolysate
por: Li, Xiaofang, et al.
Publicado: (2023)

Vaccination against Influenza with Recombinant Hemagglutinin Expressed by Schizochytrium sp. Confers Protective Immunity
por: Bayne, Anne-Cécile V., et al.
Publicado: (2013)

Complete mitochondrial genome of a DHA-rich protist Schizochytrium sp. TIO1101
por: Wang, Zhaokai, et al.
Publicado: (2016)

Propanol and 1, 3-propanediol enhance fatty acid accumulation synergistically in Schizochytrium ATCC 20888
por: Wang, Tiantian, et al.
Publicado: (2023)

Safety of Schizochytrium sp. oil as a novel food pursuant to Regulation (EU) 2015/2283
por: Turck, Dominique, et al.
Publicado: (2020)

The role of fluconazole in the regulation of fatty acid and unsaponifiable matter biosynthesis in Schizochytrium sp. MYA 1381
por: Li, Jun, et al.
Publicado: (2019)

Overproduction of docosahexaenoic acid in Schizochytrium sp. through genetic engineering of oxidative stress defense pathways
por: Han, Xiao, et al.
Publicado: (2021)

Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway
por: Ma, Wang, et al.
Publicado: (2022)

Enhancing docosahexaenoic acid production of Schizochytrium sp. by optimizing fermentation using central composite design
por: Ding, Jun, et al.
Publicado: (2022)

Low dissolved oxygen supply functions as a global regulator of the growth and metabolism of Aurantiochytrium sp. PKU#Mn16 in the early stages of docosahexaenoic acid fermentation
por: Liu, Lu, et al.
Publicado: (2023)

Function of ORFC of the polyketide synthase gene cluster on fatty acid accumulation in Schizochytrium limacinum SR21
por: Shi, Yanyan, et al.
Publicado: (2021)

Enhancement of docosahexaenoic acid (DHA) production from Schizochytrium sp. S31 using different growth medium conditions
por: Sahin, Deniz, et al.
Publicado: (2018)

A Specific Peptide with Calcium-Binding Capacity from Defatted Schizochytrium sp. Protein Hydrolysates and the Molecular Properties
por: Cai, Xixi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4t66r8seialnu6nvjbtf5t1otu