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Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Although the development of drugs that control Ras is an emerging topic in cancer therapy, no clinically applicable drug is currently available. We have previously utilized knowledge of the Wnt/β-catenin signaling-dependent mechanism of Ras protein stability regulation to identify small molecules th...

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Detalles Bibliográficos
Autores principales:	Shin, Wookjin, Lee, Sang-Kyu, Hwang, Jeong-Ha, Park, Jong-Chan, Cho, Yong-Hee, Ro, Eun Ji, Song, Yeonhwa, Seo, Haeng Ran, Choi, Kang-Yell
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994827/ https://www.ncbi.nlm.nih.gov/pubmed/29884842 http://dx.doi.org/10.1038/s12276-018-0102-5

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