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CRISPR base editors: genome editing without double-stranded breaks

The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 adaptive immunity system has been harnessed for genome editing applications across eukaryotic species, but major drawbacks, such as the inefficiency of precise base editing and off-target activities, remain. A catalytically i...

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Detalles Bibliográficos
Autores principales:	Eid, Ayman, Alshareef, Sahar, Mahfouz, Magdy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995079/ https://www.ncbi.nlm.nih.gov/pubmed/29891532 http://dx.doi.org/10.1042/BCJ20170793

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