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Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
Objective: The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these ind...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995147/ https://www.ncbi.nlm.nih.gov/pubmed/29580923 http://dx.doi.org/10.1016/j.preghy.2017.10.005 |
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author | Schmella, Mandy J. Roberts, James M. Conley, Yvette P. Ren, Dianxu Storvold, Gro L. Ingles, Sue A. Wilson, Melissa L. Staff, Anne Catherine Hubel, Carl A. |
author_facet | Schmella, Mandy J. Roberts, James M. Conley, Yvette P. Ren, Dianxu Storvold, Gro L. Ingles, Sue A. Wilson, Melissa L. Staff, Anne Catherine Hubel, Carl A. |
author_sort | Schmella, Mandy J. |
collection | PubMed |
description | Objective: The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these independent cohorts. Study design: We used a tagging single nucleotide (tSNP) approach to assess genetic variability across five ENG pathway genes (ENG, TGFβ1, TGFβR1, ALK1, and TGFβR2) in a Caucasian cohort from Norway (n = 77 preeclampsia cases & n = 63 normotensive controls) and a White Hispanic cohort from Southern California (n = 69 preeclampsia cases & n = 106 normotensive controls). Main outcome measures: Univariate analyses (Chi Square, Fisher’s Exact) and multivariate logistic regression were conducted to evaluate the association between tSNP genotype distributions and pregnancy outcome in each cohort. Logistic regression models were adjusted for maternal age at delivery, infant sex, parity, smoking during pregnancy, and pre-pregnancy BMI. Results: Although we were unable to replicate our previous SNP-specific findings (ENG rs11792480, rs10121110; TGFβR2 rs6550005; p’s > 0.05), we found that genetic variation in TGFβR1[ALK5] (rs6478974) and TGFβR2 (rs11129420, rs6802220, rs1155708, rs3773640, rs3773663) was significantly associated with preeclampsia in the Norwegian cohort and genetic variation in ALK1 (rs706819) and TGFβR2 (rs9843942) was significantly associated with preeclampsia in the Latina cohort. Conclusion: Overall, our results provide further support for the involvement and investigation of the endoglin pathway in preeclampsia. |
format | Online Article Text |
id | pubmed-5995147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59951472018-06-11 Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() Schmella, Mandy J. Roberts, James M. Conley, Yvette P. Ren, Dianxu Storvold, Gro L. Ingles, Sue A. Wilson, Melissa L. Staff, Anne Catherine Hubel, Carl A. Pregnancy Hypertens Article Objective: The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these independent cohorts. Study design: We used a tagging single nucleotide (tSNP) approach to assess genetic variability across five ENG pathway genes (ENG, TGFβ1, TGFβR1, ALK1, and TGFβR2) in a Caucasian cohort from Norway (n = 77 preeclampsia cases & n = 63 normotensive controls) and a White Hispanic cohort from Southern California (n = 69 preeclampsia cases & n = 106 normotensive controls). Main outcome measures: Univariate analyses (Chi Square, Fisher’s Exact) and multivariate logistic regression were conducted to evaluate the association between tSNP genotype distributions and pregnancy outcome in each cohort. Logistic regression models were adjusted for maternal age at delivery, infant sex, parity, smoking during pregnancy, and pre-pregnancy BMI. Results: Although we were unable to replicate our previous SNP-specific findings (ENG rs11792480, rs10121110; TGFβR2 rs6550005; p’s > 0.05), we found that genetic variation in TGFβR1[ALK5] (rs6478974) and TGFβR2 (rs11129420, rs6802220, rs1155708, rs3773640, rs3773663) was significantly associated with preeclampsia in the Norwegian cohort and genetic variation in ALK1 (rs706819) and TGFβR2 (rs9843942) was significantly associated with preeclampsia in the Latina cohort. Conclusion: Overall, our results provide further support for the involvement and investigation of the endoglin pathway in preeclampsia. Elsevier 2018-04 /pmc/articles/PMC5995147/ /pubmed/29580923 http://dx.doi.org/10.1016/j.preghy.2017.10.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schmella, Mandy J. Roberts, James M. Conley, Yvette P. Ren, Dianxu Storvold, Gro L. Ingles, Sue A. Wilson, Melissa L. Staff, Anne Catherine Hubel, Carl A. Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() |
title | Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() |
title_full | Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() |
title_fullStr | Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() |
title_full_unstemmed | Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() |
title_short | Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() |
title_sort | endoglin pathway genetic variation in preeclampsia: a validation study in norwegian and latina cohorts() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995147/ https://www.ncbi.nlm.nih.gov/pubmed/29580923 http://dx.doi.org/10.1016/j.preghy.2017.10.005 |
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