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Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()

Objective: The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these ind...

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Autores principales: Schmella, Mandy J., Roberts, James M., Conley, Yvette P., Ren, Dianxu, Storvold, Gro L., Ingles, Sue A., Wilson, Melissa L., Staff, Anne Catherine, Hubel, Carl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995147/
https://www.ncbi.nlm.nih.gov/pubmed/29580923
http://dx.doi.org/10.1016/j.preghy.2017.10.005
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author Schmella, Mandy J.
Roberts, James M.
Conley, Yvette P.
Ren, Dianxu
Storvold, Gro L.
Ingles, Sue A.
Wilson, Melissa L.
Staff, Anne Catherine
Hubel, Carl A.
author_facet Schmella, Mandy J.
Roberts, James M.
Conley, Yvette P.
Ren, Dianxu
Storvold, Gro L.
Ingles, Sue A.
Wilson, Melissa L.
Staff, Anne Catherine
Hubel, Carl A.
author_sort Schmella, Mandy J.
collection PubMed
description Objective: The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these independent cohorts. Study design: We used a tagging single nucleotide (tSNP) approach to assess genetic variability across five ENG pathway genes (ENG, TGFβ1, TGFβR1, ALK1, and TGFβR2) in a Caucasian cohort from Norway (n = 77 preeclampsia cases & n = 63 normotensive controls) and a White Hispanic cohort from Southern California (n = 69 preeclampsia cases & n = 106 normotensive controls). Main outcome measures: Univariate analyses (Chi Square, Fisher’s Exact) and multivariate logistic regression were conducted to evaluate the association between tSNP genotype distributions and pregnancy outcome in each cohort. Logistic regression models were adjusted for maternal age at delivery, infant sex, parity, smoking during pregnancy, and pre-pregnancy BMI. Results: Although we were unable to replicate our previous SNP-specific findings (ENG rs11792480, rs10121110; TGFβR2 rs6550005; p’s > 0.05), we found that genetic variation in TGFβR1[ALK5] (rs6478974) and TGFβR2 (rs11129420, rs6802220, rs1155708, rs3773640, rs3773663) was significantly associated with preeclampsia in the Norwegian cohort and genetic variation in ALK1 (rs706819) and TGFβR2 (rs9843942) was significantly associated with preeclampsia in the Latina cohort. Conclusion: Overall, our results provide further support for the involvement and investigation of the endoglin pathway in preeclampsia.
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spelling pubmed-59951472018-06-11 Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts() Schmella, Mandy J. Roberts, James M. Conley, Yvette P. Ren, Dianxu Storvold, Gro L. Ingles, Sue A. Wilson, Melissa L. Staff, Anne Catherine Hubel, Carl A. Pregnancy Hypertens Article Objective: The purpose of this study was to validate our previous genetic association findings related to the endoglin (ENG) pathway from an American Caucasian preeclampsia cohort in independent preeclampsia cohorts. We also sought to explore the ENG pathway for new genetic associations in these independent cohorts. Study design: We used a tagging single nucleotide (tSNP) approach to assess genetic variability across five ENG pathway genes (ENG, TGFβ1, TGFβR1, ALK1, and TGFβR2) in a Caucasian cohort from Norway (n = 77 preeclampsia cases & n = 63 normotensive controls) and a White Hispanic cohort from Southern California (n = 69 preeclampsia cases & n = 106 normotensive controls). Main outcome measures: Univariate analyses (Chi Square, Fisher’s Exact) and multivariate logistic regression were conducted to evaluate the association between tSNP genotype distributions and pregnancy outcome in each cohort. Logistic regression models were adjusted for maternal age at delivery, infant sex, parity, smoking during pregnancy, and pre-pregnancy BMI. Results: Although we were unable to replicate our previous SNP-specific findings (ENG rs11792480, rs10121110; TGFβR2 rs6550005; p’s > 0.05), we found that genetic variation in TGFβR1[ALK5] (rs6478974) and TGFβR2 (rs11129420, rs6802220, rs1155708, rs3773640, rs3773663) was significantly associated with preeclampsia in the Norwegian cohort and genetic variation in ALK1 (rs706819) and TGFβR2 (rs9843942) was significantly associated with preeclampsia in the Latina cohort. Conclusion: Overall, our results provide further support for the involvement and investigation of the endoglin pathway in preeclampsia. Elsevier 2018-04 /pmc/articles/PMC5995147/ /pubmed/29580923 http://dx.doi.org/10.1016/j.preghy.2017.10.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schmella, Mandy J.
Roberts, James M.
Conley, Yvette P.
Ren, Dianxu
Storvold, Gro L.
Ingles, Sue A.
Wilson, Melissa L.
Staff, Anne Catherine
Hubel, Carl A.
Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
title Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
title_full Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
title_fullStr Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
title_full_unstemmed Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
title_short Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts()
title_sort endoglin pathway genetic variation in preeclampsia: a validation study in norwegian and latina cohorts()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995147/
https://www.ncbi.nlm.nih.gov/pubmed/29580923
http://dx.doi.org/10.1016/j.preghy.2017.10.005
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