Cargando…

Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia

Onset of progression even during therapy with novel drugs remains an issue in chronic lymphocytic leukemia (CLL). Thus, there is ongoing demand for novel agents. Approaches targeting cyclin-dependent kinases (CDK) have reached the clinical trial stage. CDK9 mediating RNA transcriptional elongation i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Göthert, Joachim R., Imsak, Roze, Möllmann, Michael, Kesper, Stefanie, Göbel, Maria, Dührsen, Ulrich, Scholz, Arne, Lücking, Ulrich, Baumann, Matthias, Unger, Anke, Schultz-Fademrecht, Carsten, Klebl, Bert, Eickhoff, Jan, Choidas, Axel, Dürig, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995184/ https://www.ncbi.nlm.nih.gov/pubmed/29899864 http://dx.doi.org/10.18632/oncotarget.25293

Ejemplares similares

Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia
por: Johansson, Patricia, et al.
Publicado: (2020)

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
por: Lücking, Ulrich, et al.
Publicado: (2017)

CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo
por: Dampmann, Maria, et al.
Publicado: (2020)

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia
por: Johansson, Patricia, et al.
Publicado: (2018)

Deorphanization and characterization of the ectopically expressed olfactory receptor OR51B5 in myelogenous leukemia cells
por: Manteniotis, S, et al.
Publicado: (2016)

Progranulin Is a Novel Independent Predictor of Disease Progression and Overall Survival in Chronic Lymphocytic Leukemia
por: Göbel, Maria, et al.
Publicado: (2013)

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency
por: Schütz, Martin, et al.
Publicado: (2023)

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy
por: Dahl, Edgar, et al.
Publicado: (2022)

Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia
por: Manteniotis, S, et al.
Publicado: (2016)

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas
por: Johansson, Patricia, et al.
Publicado: (2016)

Monoclonal gammopathy of undetermined significance is associated with prostate cancer in a population-based cohort study
por: Hornung, Nicola, et al.
Publicado: (2021)

Epigenetic Silencing of the Circadian Clock Gene CRY1 is Associated with an Indolent Clinical Course in Chronic Lymphocytic Leukemia
por: Hanoun, Maher, et al.
Publicado: (2012)

A genetic risk score of alleles related to MGUS interacts with socioeconomic position in a population-based cohort
por: Baak, Lisa, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K‐Ras4b Inhibitors
por: Jeuken, Stephan, et al.
Publicado: (2022)

Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form
por: Aarhus, Thomas Ihle, et al.
Publicado: (2023)

Enforced GFI1 expression impedes human and murine leukemic cell growth
por: Hönes, Judith M., et al.
Publicado: (2017)

Air Pollution and Polyclonal Elevation of Serum Free Light Chains: An Assessment of Adaptive Immune Responses in the Prospective Heinz Nixdorf Recall Study
por: Ohlwein, Simone, et al.
Publicado: (2021)

Outcome prediction by interim positron emission tomography and IgM monoclonal gammopathy in diffuse large B-cell lymphoma
por: Johansson, Patricia, et al.
Publicado: (2023)

Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing
por: Johansson, Patricia, et al.
Publicado: (2020)

Targeting CD38 in acute myeloid leukemia interferes with leukemia trafficking and induces phagocytosis
por: Farber, Meike, et al.
Publicado: (2021)

Stacking up the armory against viruses
por: Klebl, Bert M
Publicado: (2004)

Inhibition of Cyclin-dependent Kinase (CDK) Decreased Survival of NB4 Leukemic Cells: Proposing a p53-Independent Sensitivity of Leukemic Cells to Multi-CDKs Inhibitor AT7519
por: Pourbagheri-Sigaroodi, Atieh, et al.
Publicado: (2020)

Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages
por: Görgens, André, et al.
Publicado: (2014)

Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages
por: Görgens, André, et al.
Publicado: (2015)

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target
por: Tillmanns, Julia, et al.
Publicado: (2023)

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate
por: Sagurna, Leonie, et al.
Publicado: (2023)

DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders
por: Sato, Hanae, et al.
Publicado: (2016)

Publisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
por: Johansson, Patricia, et al.
Publicado: (2023)

Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
por: Johansson, Patricia, et al.
Publicado: (2022)

Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates
por: Sirvent, Juan Alberto, et al.
Publicado: (2017)

Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice
por: Radtke, Stefan, et al.
Publicado: (2019)

The role of mitochondrial proteases in leukemic cells and leukemic stem cells
por: Mirali, Sara, et al.
Publicado: (2020)

Cyclin C: The Story of a Non-Cycling Cyclin
por: Ježek, Jan, et al.
Publicado: (2019)

Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities
por: Marchand, Tony, et al.
Publicado: (2021)

Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics
por: Chakedis, Jeffery, et al.
Publicado: (2016)

The Role of Whole-Body Magnetic Resonance Imaging (WB-MRI) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)
por: Alashkar, Ferras, et al.
Publicado: (2018)

Phosphorylation of human DNA polymerase λ by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen
por: Frouin, Isabelle, et al.
Publicado: (2005)

Leukemic Ischemia: A Case of Myocardial Infarction Secondary to Leukemic Cardiac Involvement
por: Fursevich, Dzmitry, et al.
Publicado: (2017)

Fluorouracil Selectively Enriches Stem-like Leukemic Cells in a Leukemic Cell Line
por: Zhang, Ling, et al.
Publicado: (2010)

Evaluation and management of leukolysis-mediated pseudohyperkalemia in paediatric leukemic samples
por: Peter Nonkes, Lourens Jan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_24rfn3dou1ttf22hlvpdh7vq71