VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells

PURPOSE: DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We demonstrate the selectivity of VX-984, a DNA-PK inhibitor, using assays not previously reported. EXPERIMENTAL DESIGN: The class switch recombination assay (CSR) in prima...

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Detalles Bibliográficos
Autores principales: Khan, Atif J., Misenko, Sarah M., Thandoni, Aditya, Schiff, Devora, Jhawar, Sachin R., Bunting, Samuel F., Haffty, Bruce G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995231/
https://www.ncbi.nlm.nih.gov/pubmed/29899825
http://dx.doi.org/10.18632/oncotarget.25383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995231/
https://www.ncbi.nlm.nih.gov/pubmed/29899825
http://dx.doi.org/10.18632/oncotarget.25383

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