Cargando…

VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells

PURPOSE: DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We demonstrate the selectivity of VX-984, a DNA-PK inhibitor, using assays not previously reported. EXPERIMENTAL DESIGN: The class switch recombination assay (CSR) in prima...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Atif J., Misenko, Sarah M., Thandoni, Aditya, Schiff, Devora, Jhawar, Sachin R., Bunting, Samuel F., Haffty, Bruce G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995231/ https://www.ncbi.nlm.nih.gov/pubmed/29899825 http://dx.doi.org/10.18632/oncotarget.25383

Ejemplares similares

The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo
por: Khan, Atif J., et al.
Publicado: (2019)

The spatial organization of non-homologous end joining: From bridging to end joining
por: Ochi, Takashi, et al.
Publicado: (2014)

The non-homologous end-joining pathway is involved in stable transformation in rice
por: Saika, Hiroaki, et al.
Publicado: (2014)

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair
por: Vazquez, Berta N, et al.
Publicado: (2016)

Non-homologous end joining in class switch recombination: the beginning of the end
por: Kotnis, Ashwin, et al.
Publicado: (2008)

Homology and enzymatic requirements of microhomology-dependent alternative end joining
por: Sharma, S, et al.
Publicado: (2015)

DNA non-homologous end-joining enters the resection arena
por: Jeggo, Penny A., et al.
Publicado: (2017)

Non-homologous end joining repair in Xenopus egg extract
por: Zhu, Songli, et al.
Publicado: (2016)

PIAS3 promotes homology-directed repair and distal non-homologous end joining
por: LIU, SHICUI, et al.
Publicado: (2013)

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell
por: Hussain, Suleman S, et al.
Publicado: (2021)

Making Ends Meet: Repairing Breaks in Bacterial DNA by Non-Homologous End-Joining
por: Bowater, Richard, et al.
Publicado: (2006)

End-processing during non-homologous end-joining: a role for exonuclease 1
por: Bahmed, Karim, et al.
Publicado: (2011)

Change of Gene Structure and Function by Non-Homologous End-Joining, Homologous Recombination, and Transposition of DNA
por: Goettel, Wolfgang, et al.
Publicado: (2009)

Merotelic attachments and non-homologous end joining are the basis of chromosomal instability
por: Guerrero, Astrid Alonso, et al.
Publicado: (2010)

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?
por: Bétermier, Mireille, et al.
Publicado: (2014)

Lif1 SUMOylation and its role in non-homologous end-joining
por: Vigasova, Dana, et al.
Publicado: (2013)

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer
por: Sishc, Brock J., et al.
Publicado: (2017)

Canonical DNA non-homologous end-joining; capacity versus fidelity
por: Shibata, Atsushi, et al.
Publicado: (2020)

Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer
por: Jhawar, Sachin R, et al.
Publicado: (2023)

One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks
por: Ensminger, Michael, et al.
Publicado: (2020)

A Single XLF Dimer Bridges DNA Ends During Non-Homologous End Joining
por: Graham, Thomas G.W., et al.
Publicado: (2018)

The Fate of Linear DNA in Saccharomyces cerevisiae and Candida glabrata: The Role of Homologous and Non-Homologous End Joining
por: Corrigan, Mary W., et al.
Publicado: (2013)

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
por: Szymonowicz, Klaudia, et al.
Publicado: (2020)

Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes
por: Demogines, Ann, et al.
Publicado: (2010)

Role of mammalian Mre11 in classical and alternative non-homologous end joining
por: Xie, Anyong, et al.
Publicado: (2009)

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ
por: Martin, Maria Jose, et al.
Publicado: (2013)

Modeling Damage Complexity-Dependent Non-Homologous End-Joining Repair Pathway
por: Li, Yongfeng, et al.
Publicado: (2014)

A role for protein phosphatase 4 in regulating non-homologous end-joining
por: Davis, Anthony J., et al.
Publicado: (2012)

Heat shock factor 1, an inhibitor of non-homologous end joining repair
por: Kang, Ga-Young, et al.
Publicado: (2015)

PHRF1 promotes genome integrity by modulating non-homologous end-joining
por: Chang, C-F, et al.
Publicado: (2015)

Long noncoding RNA LINP1: scaffolding non-homologous end joining
por: Sakthianandeswaren, A, et al.
Publicado: (2016)

XLF acts as a flexible connector during non-homologous end joining
por: Carney, Sean M, et al.
Publicado: (2020)

Viral interactions with non-homologous end-joining: a game of hide-and-seek
por: Hristova, Dayana B., et al.
Publicado: (2020)

Alternative splicing in multiple myeloma is associated with the non-homologous end joining pathway
por: Liu, Enze, et al.
Publicado: (2023)

Gene expression of non-homologous end-joining pathways in the prognosis of ovarian cancer
por: Lavi, Ethan S., et al.
Publicado: (2023)

ATM Limits Incorrect End Utilization during Non-Homologous End Joining of Multiple Chromosome Breaks
por: Bennardo, Nicole, et al.
Publicado: (2010)

In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining
por: Geisinger, Jonathan M., et al.
Publicado: (2016)

Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor
por: Yaneva, Mariana, et al.
Publicado: (2005)

Involvement of Caveolin-1 in Repair of DNA Damage through Both Homologous Recombination and Non-Homologous End Joining
por: Zhu, Hua, et al.
Publicado: (2010)

Functional Roles of Homologous Recombination and Non-Homologous End Joining in DNA Damage Response and Microevolution in Cryptococcus neoformans
por: Jung, Kwang-Woo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c4bakpbvj0l5ifnj15lfenqtnf