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Epigenetic dysregulation of TET2 in human glioblastoma
Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well a...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995234/ https://www.ncbi.nlm.nih.gov/pubmed/29899831 http://dx.doi.org/10.18632/oncotarget.25406 |
| _version_ | 1783330577327325184 |
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| author | García, María G. Carella, Antonella Urdinguio, Rocío G. Bayón, Gustavo F. Lopez, Virginia Tejedor, Juan Ramón Sierra, Marta I. García-Toraño, Estela Santamarina, Pablo Perez, Raúl F. Mangas, Cristina Astudillo, Aurora Corte-Torres, M. Daniela Sáenz-de-Santa-María, Inés Chiara, María-Dolores Fernández, Agustín F. Fraga, Mario F. |
| author_facet | García, María G. Carella, Antonella Urdinguio, Rocío G. Bayón, Gustavo F. Lopez, Virginia Tejedor, Juan Ramón Sierra, Marta I. García-Toraño, Estela Santamarina, Pablo Perez, Raúl F. Mangas, Cristina Astudillo, Aurora Corte-Torres, M. Daniela Sáenz-de-Santa-María, Inés Chiara, María-Dolores Fernández, Agustín F. Fraga, Mario F. |
| author_sort | García, María G. |
| collection | PubMed |
| description | Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of TET2 regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of TET2 plays a role in human glioblastoma. |
| format | Online Article Text |
| id | pubmed-5995234 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Impact Journals LLC |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59952342018-06-13 Epigenetic dysregulation of TET2 in human glioblastoma García, María G. Carella, Antonella Urdinguio, Rocío G. Bayón, Gustavo F. Lopez, Virginia Tejedor, Juan Ramón Sierra, Marta I. García-Toraño, Estela Santamarina, Pablo Perez, Raúl F. Mangas, Cristina Astudillo, Aurora Corte-Torres, M. Daniela Sáenz-de-Santa-María, Inés Chiara, María-Dolores Fernández, Agustín F. Fraga, Mario F. Oncotarget Research Paper Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of TET2 regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of TET2 plays a role in human glioblastoma. Impact Journals LLC 2018-05-25 /pmc/articles/PMC5995234/ /pubmed/29899831 http://dx.doi.org/10.18632/oncotarget.25406 Text en Copyright: © 2018 García et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Research Paper García, María G. Carella, Antonella Urdinguio, Rocío G. Bayón, Gustavo F. Lopez, Virginia Tejedor, Juan Ramón Sierra, Marta I. García-Toraño, Estela Santamarina, Pablo Perez, Raúl F. Mangas, Cristina Astudillo, Aurora Corte-Torres, M. Daniela Sáenz-de-Santa-María, Inés Chiara, María-Dolores Fernández, Agustín F. Fraga, Mario F. Epigenetic dysregulation of TET2 in human glioblastoma |
| title | Epigenetic dysregulation of TET2 in human glioblastoma |
| title_full | Epigenetic dysregulation of TET2 in human glioblastoma |
| title_fullStr | Epigenetic dysregulation of TET2 in human glioblastoma |
| title_full_unstemmed | Epigenetic dysregulation of TET2 in human glioblastoma |
| title_short | Epigenetic dysregulation of TET2 in human glioblastoma |
| title_sort | epigenetic dysregulation of tet2 in human glioblastoma |
| topic | Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995234/ https://www.ncbi.nlm.nih.gov/pubmed/29899831 http://dx.doi.org/10.18632/oncotarget.25406 |
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