Cargando…

CHL1 gene acts as a tumor suppressor in human neuroblastoma

Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system that accounts for 15% of pediatric cancer deaths. A distal portion of human chromosome 3p is often deleted in neuroblastoma, this region may contain one or more putative tumor suppressor genes. A 2.54 Mb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ognibene, Marzia, Pagnan, Gabriella, Marimpietri, Danilo, Cangelosi, Davide, Cilli, Michele, Benedetti, Maria Chiara, Boldrini, Renata, Garaventa, Alberto, Frassoni, Francesco, Eva, Alessandra, Varesio, Luigi, Pistoia, Vito, Pezzolo, Annalisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995240/ https://www.ncbi.nlm.nih.gov/pubmed/29899830 http://dx.doi.org/10.18632/oncotarget.25403

Ejemplares similares

Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma
por: Ognibene, Marzia, et al.
Publicado: (2020)

Role of GOLPH3 and TPX2 in Neuroblastoma DNA Damage Response and Cell Resistance to Chemotherapy
por: Ognibene, Marzia, et al.
Publicado: (2019)

Neuroblastoma Cell Lines Are Refractory to Genotoxic Drug-Mediated Induction of Ligands for NK Cell-Activating Receptors
por: Veneziani, Irene, et al.
Publicado: (2018)

Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma
por: Ognibene, Marzia, et al.
Publicado: (2020)

Proteome Profiling of Neuroblastoma-Derived Exosomes Reveal the Expression of Proteins Potentially Involved in Tumor Progression
por: Marimpietri, Danilo, et al.
Publicado: (2013)

High Grade of Amplification of Six Regions on Chromosome 2p in a Neuroblastoma Patient with Very Poor Outcome: The Putative New Oncogene TSSC1
por: Ognibene, Marzia, et al.
Publicado: (2021)

Multiple Genes with Potential Tumor Suppressive Activity Are Present on Chromosome 10q Loss in Neuroblastoma and Are Associated with Poor Prognosis
por: Ognibene, Marzia, et al.
Publicado: (2023)

Intratumoral diversity of telomere length in individual neuroblastoma tumors
por: Pezzolo, Annalisa, et al.
Publicado: (2014)

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia
por: Pezzolo, Annalisa, et al.
Publicado: (2014)

The Over-Expression of E2F3 Might Serve as Prognostic Marker for Neuroblastoma Patients with Stage 4S Disease
por: Parodi, Stefano, et al.
Publicado: (2020)

Molecular Genetics in Neuroblastoma Prognosis
por: Lerone, Margherita, et al.
Publicado: (2021)

Immunosuppressive Microenvironment in Neuroblastoma
por: Pistoia, Vito, et al.
Publicado: (2013)

Neuroblastoma Patients’ Outcome and Chromosomal Instability
por: Ognibene, Marzia, et al.
Publicado: (2023)

A Simple, Test-Based Method to Control the Overestimation Bias in the Analysis of Potential Prognostic Tumour Markers
por: Ognibene, Marzia, et al.
Publicado: (2023)

Immunohistochemical analysis of PDK1, PHD3 and HIF-1α expression defines the hypoxic status of neuroblastoma tumors
por: Ognibene, Marzia, et al.
Publicado: (2017)

MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma
por: Brandetti, Elisa, et al.
Publicado: (2017)

Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells
por: Degli Esposti, Chiara, et al.
Publicado: (2021)

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis
por: Lasorsa, Vito Alessandro, et al.
Publicado: (2020)

Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study (‖)
por: Morini, Martina, et al.
Publicado: (2019)

Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy
por: Pistoia, Vito, et al.
Publicado: (2016)

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas
por: Cantilena, Sandra, et al.
Publicado: (2011)

Genomic Analysis Made It Possible to Identify Gene-Driver Alterations Covering the Time Window between Diagnosis of Neuroblastoma 4S and the Progression to Stage 4
por: Ognibene, Marzia, et al.
Publicado: (2022)

Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients
por: Cangelosi, Davide, et al.
Publicado: (2013)

The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
por: Grasso, Silvia, et al.
Publicado: (2019)

ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
por: Bianchi, G, et al.
Publicado: (2014)

Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming
por: Cangelosi, Davide, et al.
Publicado: (2020)

CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma
por: Wachowiak, Robin, et al.
Publicado: (2019)

Favorable prognostic role of tropomodulins in neuroblastoma
por: Bettinsoli, Paola, et al.
Publicado: (2018)

MYCN: from oncoprotein to tumor-associated antigen
por: Pistoia, Vito, et al.
Publicado: (2012)

Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome
por: Brandetti, Elisa, et al.
Publicado: (2021)

Close Interactions between Mesenchymal Stem Cells and Neuroblastoma Cell Lines Lead to Tumor Growth Inhibition
por: Bianchi, Giovanna, et al.
Publicado: (2012)

The Role of Extracellular Vesicles in the Progression of Human Neuroblastoma
por: Marimpietri, Danilo, et al.
Publicado: (2021)

Artificial neural network classifier predicts neuroblastoma patients’ outcome
por: Cangelosi, Davide, et al.
Publicado: (2016)

Connectivity Map Analysis Indicates PI3K/Akt/mTOR Inhibitors as Potential Anti-Hypoxia Drugs in Neuroblastoma
por: Uva, Paolo, et al.
Publicado: (2021)

Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients
por: Cangelosi, Davide, et al.
Publicado: (2014)

Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells
por: Pisano, Marina, et al.
Publicado: (2010)

Plasma-Derived Exosome Proteins as Novel Diagnostic and Prognostic Biomarkers in Neuroblastoma Patients
por: Morini, Martina, et al.
Publicado: (2023)

Angiogenesis in a human neuroblastoma xenograft model: mechanisms and inhibition by tumour-derived interferon-γ
por: Ribatti, D, et al.
Publicado: (2006)

Pyrazole-Enriched Cationic Nanoparticles Induced Early- and Late-Stage Apoptosis in Neuroblastoma Cells at Sub-Micromolar Concentrations
por: Zuccari, Guendalina, et al.
Publicado: (2023)

Induction of Epithelial Mesenchimal Transition and Vasculogenesis in the Lenses of Dbl Oncogene Transgenic Mice
por: Fardin, Paolo, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_0119ivqgvqav27nogumlg6qfjg