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BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

Cancer cells display differences regarding their engagement of glycolytic vs. mitochondrial oxidative phosphorylation (OXPHOS) pathway. Triple negative breast cancer, an aggressive form of breast cancer, is characterized by elevated glycolysis, while estrogen receptor positive breast cancer cells re...

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Detalles Bibliográficos
Autores principales:	Lucantoni, Federico, Düssmann, Heiko, Llorente-Folch, Irene, Prehn, Jochen H.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995245/ https://www.ncbi.nlm.nih.gov/pubmed/29899841 http://dx.doi.org/10.18632/oncotarget.25433

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