Suppression of focal adhesion formation may account for the suppression of cell migration, invasion and growth of non-small cell lung cancer cells following treatment with polyisoprenylated cysteinyl amide inhibitors

Migratory cells form extracellular matrix attachments called focal-adhesions. Focal adhesion assembly and disassembly are regulated by the Rho family of small GTPases. We previously reported that polyisoprenylated cysteinyl amide inhibitors (PCAIs) suppress Rho protein levels, disrupting F-actin cyt...

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Detalles Bibliográficos
Autores principales: Ntantie, Elizabeth, Allen, Michaela J., Fletcher, Jerrine, Nkembo, Augustine T., Lamango, Nazarius S., Ikpatt, Offiong F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995249/
https://www.ncbi.nlm.nih.gov/pubmed/29899821
http://dx.doi.org/10.18632/oncotarget.25372

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